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Dr Andrew Grace

Research Interests

My research focuses on characterising the properties of the heart that provide the ‘substrate’ for arrhythmias. The central hypothesis is that the determinants of arrhythmic risk including atrial and ventricular fibrillation lie within the heart itself and that much of this risk is genetic.

Our team's core activities are therefore concerned with linking genetic alterations determining fibrillation syndromes to arrhythmogenic phenotypes through the use of mouse and human induced pluripotent stem cell (iPSC) models.

My clinical research involves electrophysiological phenotyping and is firmly based on the laboratory models. A large, wide-ranging referral base allows the efficient delivery of this translational limb of the program. I have also developed links with industry based on translational principles that provide novel approaches (drugs and devices) for patient management - largely based on the insights obtained through the pre-clinical programmes.

Keywords

cardiac arrhythmia ; cardiac re-synchronisation

Topics

  • Atrial fibrillation

Key Publications

Ion channels, long QT syndrome and arrhythmogenesis in ageing. Jeevaratnam K, Chadda KR, Salvage SC, Valli H, Ahmad S, Grace AA, Huang CL. Clin Exp Pharmacol Physiol. 2016 Dec 26.

The learning curve associated with the introduction of the subcutaneous implantable defibrillator. Knops RE, Brouwer TF, Barr CS, Theuns DA, Boersma L, Weiss R, Neuzil P, Scholten M, Lambiase PD, Leon AR, Hood M, Jones PW, Wold N, Grace AA, Olde Nordkamp LR, Burke MC; IDE and EFFORTLESS investigators. Europace. 2016 Jul;18(7):1010-5.

Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis. Jeevaratnam K, Guzadhur L, Goh YM, Grace AA, Huang CL. Acta Physiol (Oxf). 2016 Feb;216(2):186-202.

Cardiac resynchronisation therapy: pacemaker versus internal cardioverter-defibrillator in patients with impaired left ventricular function. Looi KL, Gajendragadkar PR, Khan FZ, Elsik M, Begley DA, Fynn SP, Grace AA, Heck PM, Virdee M, Agarwal S. Heart. 2014 May;100(10):794-9.

Common threads in atrial fibrillation and heart failure. Grace AA, Narayan SM. Heart Fail Clin. 2013 Oct;9(4):373-83, vii.

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts. Matthews GD, Guzadhur L, Sabir IN, Grace AA, Huang CL. J Physiol. 2013 Sep 1;591(Pt 17):4167-88.

Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation. King JH, Wickramarachchi C, Kua K, Du Y, Jeevaratnam K, Matthews HR, Grace AA, Huang CL, Fraser JA. Cardiovasc Res. 2013 Sep 1;99(4):751-9.

Conscious sedation and analgesia use in cardiac device implantation. Looi KL, Lee AS, Cole K, Agarwal S, Heck PM, Begley DA, Grace AA, Virdee M, Fynn SP. Int J Cardiol. 2013 Sep 20;168(1):561-3.

Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. Zhang Y, Wu J, Jeevaratnam K, King JH, Guzadhur L, Ren X, Grace AA, Lei M, Huang CL, Fraser JA. J Cardiovasc Electrophysiol. 2013 Feb;24(2):210-8.

Systems biology and cardiac arrhythmias. Grace AA, Roden DM. Lancet. 2012 Oct 27;380(9852):1498-508.

Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and sex. Jeevaratnam K, Rewbury R, Zhang Y, Guzadhur L, Grace AA, Lei M, Huang CL. Mech Ageing Dev. 2012 Sep-Oct;133(9-10):591-9.

Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2-P2328S hearts. King JH, Zhang Y, Lei M, Grace AA, Huang CL, Fraser JA. Acta Physiol (Oxf). 2013 Feb;207(2):308-23.

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