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Dr Havovi Chichger

Research Interests

My research focuses on the cellular mechanisms which regulate the vasculature, including barrier integrity, proliferation, apoptosis and the angiogenic process.  In particular, I am interested in understanding mechanisms to reduce vascular dysfunction in settings of pulmonary diseases (Acute respiratory distress syndrome, Pulmonary hypertension, Pulmonary fibrosis and microvascular complications (Diabetes, Metabolic syndrome). 

My research has implicated various novel mechanisms in the regulation of vascular function, such as, endosomal adaptor proteins (LAMTOR and Rab), protein phosphatases (PTP and SHP) and protein kinases (MAPK and PKC).  My principal research is focused on studying the role of artificial sweeteners in regulating endothelial cell function, with the aim of reducing complications in settings of vascular disease.

Keywords

microvascular complications ; endocytic trafficking ; pulmonary hypertension ; pulmonary arterial hypertension ; acute respiratory distress syndrome ; angiogenesis ; endothelial cell biology ; diabetes

Collaborators outside this directory

Key Publications

SH2 Domain-Containing Protein Tyrosine Phosphatase 2 and Focal Adhesion Kinase Protein Interactions Regulate Pulmonary Endothelium Barrier Function. Chichger H, Braza J, Duong H, Harrington EO. Am J Respir Cell Mol Biol. 2015 Jun;52(6):695-707.

PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension. Chichger H, Vang A, O'Connell KA, Zhang P, Mende U, Harrington EO, Choudhary G. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L827-36.

p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. Chichger H, Duong H, Braza J, Harrington EO. FASEB J. 2015 Mar;29(3):868-81.

Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial sodium channel (ENaC). Jacquillet G, Chichger H, Unwin RJ, Shirley DG. Nephrol Dial Transplant. 2013 Apr;28(4):839-45.

Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury. Chichger H, Grinnell KL, Casserly B, Chung CS, Braza J, Lomas-Neira J, Ayala A, Rounds S, Klinger JR, Harrington EO. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 15;303(10):L880-8.

Protection against LPS-induced pulmonary edema through the attenuation of protein tyrosine phosphatase-1B oxidation. Grinnell KL, Chichger H, Braza J, Duong H, Harrington EO. Am J Respir Cell Mol Biol. 2012 May;46(5):623-32.

Chichger H, Grinnell KL, Harrington EO.  Chapter 2: Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance. In: Electric Cell-Substrate Impedance Sensing and Cancer Metastasis.  Wengou G. Jiang (Editor).  Springer, 2012.

Alterations of sucrose preference after Roux-en-Y gastric bypass. Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CW. Physiol Behav. 2011 Oct 24;104(5):709-21.

On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding. Cesková P, Chichger H, Wallace M, Vojtesek B, Hupp TR. J Mol Biol. 2006 Mar 24;357(2):442-56.

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