skip to primary navigationskip to content
 

Dr Janet Maguire

Dr Janet Maguire

Senior Research Associate


Office Phone: 01223 762579

Research Interests

My research focuses on the pharmacology of established and novel G-protein coupled receptors (GPCRs) and their endogenous ligands in the human cardiovascular system. I am particularly interested in the role of GPCRs in vascular reactivity and how these may change with disease. An ongoing interest is in the endothelin system and the relative contribution of the two endothelin receptor subtypes to mediate the detrimental effects of endothelin in for example atherosclerosis and pulmonary arterial hypertension.

Current research is on the chemokine GPCR CCR5, an important co-receptor for HIV-1 infection that has an emerging role in the initiation and development of atherosclerosis.

The objective is to use human tissues and animal models to provide proof of principle that blockade of CCR5 will be atheroprotective, reducing both vasospasm and the development of intimal hyperplasia. If our data support this hypothesis, then the availability of the first selective antagonist introduced for clinical use in HIV infection allows for the rapid translation of this drug class into a new therapeutic area.

Keywords

G-protein coupled receptors ; Endothelin

Collaborators

Key Publications

Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. Maguire JJ, Davenport AP. Br J Pharmacol. 2014 Dec;171(24):5555-72.

Changes in biomechanical properties of the coronary artery wall contribute to maintained contractile responses to endothelin-1 in atherosclerosis. Ooi CY, Sutcliffe MP, Davenport AP, Maguire JJ. Life Sci. 2014 Nov 24;118(2):424-9.

Characterization of [¹²⁵I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta. Kuc RE, Maguire JJ, Siew K, Patel S, Derksen DR, Margaret Jackson V, O'Shaughnessey KM, Davenport AP. Life Sci. 2014 May 2;102(2):134-8.

Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension. Kuc RE, Carlebur M, Maguire JJ, Yang P, Long L, Toshner M, Morrell NW, Davenport AP. Life Sci. 2014 Nov 24;118(2):391-6.

The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro. Maguire JJ, Jones KL, Kuc RE, Clarke MC, Bennett MR, Davenport AP. Cardiovasc Res. 2014 Mar 1;101(3):513-21.

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation. Zheng Y, Humphry M, Maguire JJ, Bennett MR, Clarke MC. Immunity. 2013 Feb 21;38(2):285-95.

Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. Ling L, Maguire JJ, Davenport AP. Br J Pharmacol. 2013 Jan;168(2):283-95.

Radioligand binding assays and their analysis. Maguire JJ, Kuc RE, Davenport AP. Methods Mol Biol. 2012;897:31-77.

Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Maguire JJ, Kuc RE, Davenport AP. Life Sci. 2012 Oct 15;91(13-14):681-6.

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Seed A, Kuc RE, Maguire JJ, Hillier C, Johnston F, Essers H, de Voogd HJ, McMurray J, Davenport AP. Life Sci. 2012 Oct 15;91(13-14):743-8.

Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways. Maguire JJ, Kuc RE, Pell VR, Green A, Brown M, Kumar S, Wehrman T, Quinn E, Davenport AP. Life Sci. 2012 Oct 15;91(13-14):544-9.

Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice. Ling L, Kuc RE, Maguire JJ, Davie NJ, Webb DJ, Gibbs P, Alexander GJ, Davenport AP. Life Sci. 2012 Oct 15;91(13-14):716-22.

Logo design by Dr Ana-Mishel Spiroski and Dr Sarah Morgan.

 

We connect cardiovascular researchers in Cambridge.

Please follow us on Twitter for local news about research, events, funding calls, and open positions.

For inquiries about our research or the website, please contact Dr Katja Kivinen.