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Dr Nicholas Evans

Dr Nicholas Evans

Clinical Research Fellow


Research themes

Imaging:

Research Interests

Multimodal Molecular Imaging of Carotid Atheroinflammation and its Role in Stroke Severity and Recovery. 

Carotid artery stenosis is a major cause of stroke. The narrowing of these arteries is caused by atheroma; fatty deposits that cause ‘furring up’ of the arteries. Inflammation within atheroma is known to be associated with atheroma rupture and formation of blood clots that may break off and trigger strokes (thromboemboli). What is not known is how this affects recovery in the longer term.

My research uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to assess different patterns of inflammation within the carotid arteries of participants who have had a stroke due to carotid artery stenosis. This is then compared to the severity and recovery from stroke assessed using clinical and radiological techniques. The research considers not only the physical effects of a stroke but also the effects upon cognition and psychological wellbeing. Understanding how inflammation affects these outcomes will have important implications for risk stratification, prognostication, and patient-centred rehabilitation.

 

Key Publications

 

  1. Stoker TB, Evans NR, Warburton EA. Internal Carotid Artery Dissection. Br J Hosp Med [In press].

  2. Sriranjan RS, Tarkin JM, Evans NR, Chowdhury MM, Rudd JR. Imaging unstable plaque. Q J Nucl Med Mol Imaging 2016 [Epub ahead of print].

  3. Stoker TB, Evans NR. Managing Risk After Intracerebral Hemorrhage in Concomitant Atrial Fibrillation and Cerebral Amyloid Angiopathy. Stroke 2016 [Epub ahead of print].

  4. Evans NR, Tarkin JM, Chowdhury MM, Warburton EA, Rudd JH. PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology. Curr Atheroscler Rep 2016;18(6):30-42.

  5. Tarkin JM, Dweck MR, Evans NR, Takx R, Brown AJ, Tawakol A, Fayad ZA, Rudd JHF. Imaging Atherosclerosis. Circ Res 2016;118(4):750-69.

  6. Evans NR, Harper V, Scoffings DJ, Warburton EA. Running, ischaemic stroke and carotid artery dissection. QJM 2015;108(12):973-4.

 

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