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Professor Richard Farndale

Professor Richard Farndale

Professor of Matrix Biochemistry


Research themes

Stem Cells:

Departments and Institutes

Cardiovascular Strategic Research Initiative:
Steering Committee; Executive Committee
Department of Biochemistry:
Professor of Matrix Biochemistry
BHF Cambridge Centre of Excellence:

Keywords

collagen binding proteins ; collagen receptors ; regenerative medicine

Key Publications

 

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, Hamzeh-Cognasse H, Cognasse F, Garraud O, Nigrovic PA, Guderley H, Lacroix S, Thibault L, Semple JW, Gelb MH, Boilard E. Blood. 2014 Oct 2;124(14):2173-83.

Identification of platelet function defects by multi-parameter assessment of thrombus formation. de Witt SM, Swieringa F, Cavill R, Lamers MM, van Kruchten R, Mastenbroek T, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JW, Cosemans JM. Nat Commun. 2014 Jul 16;5:4257.

Integrin recognition motifs in the human collagens. Hamaia S, Farndale RW. Adv Exp Med Biol. 2014;819:127-42.

The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage. Howes JM, Bihan D, Slatter DA, Hamaia SW, Packman LC, Knauper V, Visse R, Farndale RW. J Biol Chem. 2014 Aug 29;289(35):24091-101.

NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization. Chow WY, Rajan R, Muller KH, Reid DG, Skepper JN, Wong WC, Brooks RA, Green M, Bihan D, Farndale RW, Slatter DA, Shanahan CM, Duer MJ. Science. 2014 May 16;344(6185):742-6.

New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay. Li XW, Rees JS, Xue P, Zhang H, Hamaia SW, Sanderson B, Funk PE, Farndale RW, Lilley KS, Perrett S, Jackson AP. J Biol Chem. 2014 May 23;289(21):14434-47.

Dynamic analysis of platelet deposition to resolve platelet adhesion receptor activity in whole blood at arterial shear rate. Pugh N, Bihan D, Perry DJ, Farndale RW. Platelets. 2014 Mar 28.

FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils. Tersteeg C, Heijnen HF, Eckly A, Pasterkamp G, Urbanus RT, Maas C, Hoefer IE, Nieuwland R, Farndale RW, Gachet C, de Groot PG, Roest M. Circ Res. 2014 Feb 28;114(5):780-91.

Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. Sage SO, Pugh N, Farndale RW, Harper AG. Physiol Rep. 2013 Oct;1(5):e00085.

An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens. Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RW. PLoS One. 2013 Jul 29;8(7):e69833.

Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation. Bleijerveld OB, van Holten TC, Preisinger C, van der Smagt JJ, Farndale RW, Kleefstra T, Willemsen MH, Urbanus RT, de Groot PG, Heck AJ, Roest M, Scholten A. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1538-43.

More publications available through PubMed.

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