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Professor Roger Pedersen

Professor Roger Pedersen

Office Phone: 01223 763236

Research themes

Stem Cells:

Keywords

development ; pluripotency ; mesoderm differentiation ; stem cells

Key Publications

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, Ghevaert C. Nat Commun. 2016 Apr 7;7:11208.

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Iyer D, Gambardella L, Bernard WG, Serrano F, Mascetti VL, Pedersen RA, Sinha S, Talasila A. Development. 2016 Mar 1;143(5):904.

Human-Mouse Chimerism Validates Human Stem Cell Pluripotency. Mascetti VL, Pedersen RA. Cell Stem Cell. 2016 Jan 7;18(1):67-72.

Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization. Bertacchi M, Lupo G, Pandolfini L, Casarosa S, D'Onofrio M, Pedersen RA, Harris WA, Cremisi F. Stem Cell Reports. 2015 Oct 13;5(4):532-45.

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells. Faial T, Bernardo AS, Mendjan S, Diamanti E, Ortmann D, Gentsch GE, Mascetti VL, Trotter MW, Smith JC, Pedersen RA. Development. 2015 Jun 15;142(12):2121-35.

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Iyer D, Gambardella L, Bernard WG, Serrano F, Mascetti VL, Pedersen RA, Talasila A, Sinha S. Development. 2015 Apr 15;142(8):1528-41.

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Bertero A, Madrigal P, Galli A, Hubner NC, Moreno I, Burks D, Brown S, Pedersen RA, Gaffney D, Mendjan S, Pauklin S, Vallier L. Genes Dev. 2015 Apr 1;29(7):702-17.

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Mononuclear Cells Using Sendai Virus. Soares FA, Pedersen RA, Vallier L. Methods Mol Biol. 2016;1357:23-31.

An important role of endothelial hairy-related transcription factors in mouse vascular development. Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, Sakai C, Itoh M, Sato GE, Hashimoto A, Fujita M, Okumura K, Araki M, Xin M, Pedersen RA, Utset MF, Kimura H, Nakagawa O. Genesis. 2014 Nov;52(11):897-906.

NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. Mendjan S, Mascetti VL, Ortmann D, Ortiz M, Karjosukarso DW, Ng Y, Moreau T, Pedersen RA. Cell Stem Cell. 2014 Sep 4;15(3):310-25.

Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells. Cheung C, Bernardo AS, Pedersen RA, Sinha S. Nat Protoc. 2014 Apr;9(4):929-38.

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? Roberts RM, Loh KM, Amita M, Bernardo AS, Adachi K, Alexenko AP, Schust DJ, Schulz LC, Telugu BP, Ezashi T, Pedersen RA. Reproduction. 2014 Apr 10;147(5):D1-12.

Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions. Soares FA, Chandra A, Thomas RJ, Pedersen RA, Vallier L, Williams DJ. J Biotechnol. 2014 Mar 10;173:53-8.

Naiveté of the human pluripotent stem cell. Mascetti VL, Pedersen RA. Nat Biotechnol. 2014 Jan;32(1):68-70.

Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Fordham RP, Yui S, Hannan NR, Soendergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB. Cell Stem Cell. 2013 Dec 5;13(6):734-44.

More publications are available through PubMed.

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