Research
Glycoprotein VI (GPVI) is a platelet-specific collagen receptor. When GPVI engages collagen, a signalling cascade is initiated, leading to platelet activation, aggregation, and thrombus formation.
In the injured vasculature, hyperactive platelets bind to exposed subendothelial collagen, forming thrombi that can detach and occlude near or distal vessels resulting in ischaemic heart disease or stroke. Therefore, controlling the activity of GPVI offers a way to control thrombosis.
Publications
Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K. J Exp Med. 2015 Feb 9;212(2):129-37.
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. Jung SM, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt MC, Gardiner EE, Howes JM, Pugh N, Bihan D, Watson SP, Farndale RW. J Biol Chem. 2012 Aug 24;287(35):30000-13.
Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow? Jung SM, Sonoda M, Tsuji K, Jimi A, Nomura S, Kanaji T, Moroi M. Platelets. 2010;21(2):101-11.
Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs. Jung SM, Tsuji K, Moroi M. J Thromb Haemost. 2009 Aug;7(8):1347-55.
