The BHF Oxbridge CRM brings together 26 world-leading research groups (13 based in Oxford, 12 based in Cambridge, and 1 based in Bristol) integrating expertise in cardiovascular repair and regeneration (Oxford), and wound healing (Bristol), with major focus on stem cells and genetics in the context of regeneration (Cambridge).
The Centre Director is Prof Paul Riley (Oxford) with leadership for Cambridge part of the Centre provided by Prof Martin Bennett. The Centre is coordinated by Dr Tertia Softley (Oxford) and Dr Katja Kivinen (Cambridge)
The Centre will bridge the principles of cardiovascular development, stem cell biology, cardiac physiology, and medicine from basic research towards biomedical applications.
Our research themes are:
- Cardiovascular stem cell physiology
- Human developmental models of cardiovascular diseases
- Resolving inflammation/fibrosis in the context of regeneration
The concept underlying the BHF Oxbridge CRM is that the coalescence of basic stem cell and developmental biology with translational research is key to underpin effective future clinical applications.
The Centre is designed to be truly collaborative across the partner universities with projects led jointly by Principal Investigators from Bristol, Cambridge, and Oxford. In addition, spending time alternately in Cambridge, Oxford and Bristol under joint supervision.has been established with
Our aims are:
- To provide new insights into cardiovascular stem cell function and potency
- To harness the capacity of endogenous stem cell and progenitor cells for repair and regeneration
- To exploit stem cells as tools for studying the molecular pathogenesis of human diseases and discovery of therapeutic agents
- To nurture future generations of cardiovascular stem cell scientists in an intellectually invigorating environment of basic and translational research.
The BHF Oxbridge CRM is one of BHF Centres of Regenerative Medicine, with the other Centres based in Imperial College London and the University of Edinburgh. All three Centres are funded by the BHF Mending Broken Hearts Appeal.