BHF Oxbridge Centre of Regenerative Medicine brings together world-leading basic and translational research groups under three overlapping themes:
- Cardiovascular stem cell physiology
- Human developmental models of cardiovascular disease
- Resolving inflammation/fibrosis in the context of regeneration
Please follow the links below to read more about the research our investigators do.
The Principle Investigators from the 2017-2021 CRM:
Name | Location | Focus |
---|---|---|
Dr Sanjay Sinha | Cambridge | Use of embryonic stem cells to model SMC differentiation for vascular disease and drug screening |
Prof Martin Bennett | Cambridge | Role of progenitor cells in vascular disease |
Dr Cedric Ghevaert | Cambridge | High-throughput production of blood cells from haematopoietic or pluripotent stem cells |
Dr Helle Jørgensen | Cambridge | Epigenetic regulation in cardiovascular differentiation |
Prof Ludovic Vallier | Cambridge | Endoderm differentiation and use of iPSCs for modelling disease and drug development |
Prof Enrique Amaya | Manchester | THE MOLECULAR AND CELLULAR BASIS OF TISSUE FORMATION, REPAIR AND REGENERATION |
Prof Paul Martin | Bristol | Inflammation in repair and cancer |
Dr Beck Richardson | Bristol | The role of inflammatory cell signalling in tissue repair |
A Prof Nicola Smart | Oxford | Cardiovascular Development and Regeneration |
Prof Angela Russell |
Oxford |
My work focuses on the discovery of new drug targets and mechanisms, and the translation of these findings into new clinical candidates. |
Prof Roger Patient | Oxford | Blood and cardiovascular development, with a particular focus on stem cells |
Prof Paul Riley | Oxford | Programming the failing heart to a regenerative state |
Prof Shoumo Bhattacharya | Oxford | Transcription factor and signalling networks in cardiogenesis |
Prof Robin Choudhury | Oxford | Functional imaging of atherosclerosis and vascular disease |
The Centre Collaborators from 2017-2021 CRM:
Name | Location | Focus |
---|---|---|
Dr Amer Rana | Cambridge | Pluripotency and direct nuclear programming: viable cell and gene therapies (PAH) |
Prof Serena Best | Cambridge | Collagen scaffolds |
Prof Ruth Cameron | Cambridge |
Tissue Engineering |
Prof Bertie Göttgens | Cambridge | Transcriptional Regulation of Blood Stem cells |
Prof Keith Channon | Oxford | Nitric oxide and redox signalling in cardiovascular disease |
Dr Matt Daniels | Oxford | Inherited heart disease |
Dr Sarah De Val | Oxford | Blood vessels grow, differentiate and regress through studying the transcriptional regulation of vascular genes. |
Prof David Greaves | Oxford | Inflammation is the response of vascularised tissues to injury, metabolic disturbance and infection. |
A Prof Mathilda Mommersteeg | Oxford | Heart regeneration in Mexican cavefish |
Prof Jurgen Schneider | Oxford | Development of fast cardiac MRI techniques at ultra-high fields |
Prof Shankar Srinivas |
Oxford |
Time-lapse microscopy approaches |
Prof Ellie Tzima | Oxford | cardiovascular system, acting as regulators of vascular physiology and pathology |
Dr Shane Herbert | Manchester | Communal coordination of cell behaviour underpinning organ formation |
Dr Kimberly Mace | Manchester | Regulation of adult stem cell recruitment, engraftment, and differentiation during tissue repair and regeneration |
Prof Chuck Murray | Washington | Mechanisms that underlie cardiovascular disease and to develop new treatments |
The Principle Investigators from the 2013-2017 CRM:
Name | Location | Focus |
---|---|---|
Prof Martin Bennett | Cambridge | Role of progenitor cells in vascular disease |
Prof Kevin Brindle | Cambridge | Imaging for non-invasive tracking of cells in vivo |
Dr Cedric Ghevaert | Cambridge | High-throughput production of blood cells from haematopoietic or pluripotent stem cells |
Dr Helle Jørgensen | Cambridge | Epigenetic regulation in cardiovascular differentiation |
Prof Nick Morrell | Cambridge | Using iPSCs to model pulmonary arterial hypertension and drug screening |
Prof Roger Pedersen | Cambridge | Maintenance of hESC pluripotency and pathways for early cardiomyocyte differentiation |
Dr Amer Rana | Cambridge | Pluripotency and direct nuclear programming: viable cell and gene therapies (PAH) |
Dr Sanjay Sinha | Cambridge | Use of embryonic stem cells to model SMC differentiation for vascular disease and drug screening |
Prof Austin Smith | Cambridge | Stem cell self-renewal and commitment: pluripotency and lineage choice |
Prof Ludovic Vallier | Cambridge | Endoderm differentiation and use of iPSCs for modelling disease and drug development |
Prof Karl Laugwitz |
Cambridge / Munich |
hPSC for cardiovascular disease modelling: heart development |
Prof Alessandra Moretti | Cambridge / Munich | hPSC for the molecular characterisation of cardiovascular disease |
Prof Paul Riley | Oxford | Programming the failing heart to a regenerative state |
Prof Shoumo Bhattacharya | Oxford | Transcription factor and signalling networks in cardiogenesis |
Prof Robin Choudhury | Oxford | Functional imaging of atherosclerosis and vascular disease |
Dr Paul Fairchild | Oxford | Stem cell biology and immunology: transplantation tolerance |
Prof David Greaves | Oxford | Inflammation: macrophage and SMC recruitment |
Prof Sten Erik Jacobsen | Oxford | Regulation of haematopoietic stem cell fate and lineage development |
Prof Roger Patient | Oxford | Programming blood and the cardiovascular system |
Dr Jurgen Schneider | Oxford | Development of fast cardiac MRI: functional imaging |
Dr Shankar Srinivas | Oxford | Cell movement and fate during mammalian embryogenesis: early heart development |
Prof Hugh Watkins | Oxford | Molecular genetics of heart muscle disease and complex cardiovascular traits |
Dr Matthew Daniels | Oxford | Stem cell derived models of inherited heart disease |
Dr Nicola Smart | Oxford | Coronary vascular development and disease |
Dr Mathilda Mommersteeg | Oxford | Cave fish heart regeneration |
Prof Paul Martin | Bristol | Inflammation in wound healing |