Research
Mitochondrial function in health and disease
My research is concerned with mitochondrial function:
- how this is altered in metabolic diseases, during development and ageing, and with changes in diet, exercise and oxygen
- what effects these changes have on physiological performance.
We aim to elucidate the causes of mitochondrial dysfunction and the impact this has on function at the level of the tissue, intact organ and whole body.
Publications
Most recent publications are listed on PubMed.
Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. Ashmore T, Roberts LD, Morash AJ, Kotwica AO, Finnerty J, West JA, Murfitt SA, Fernandez BO, Branco C, Cowburn AS, Clarke K, Johnson RS, Feelisch M, Griffin JL, Murray AJ. BMC Biol. 2015 Dec 22;13:110.
Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Roberts LD, Ashmore T, Kotwica AO, Murfitt SA, Fernandez BO, Feelisch M, Murray AJ, Griffin JL. Diabetes. 2015 Feb;64(2):471-84.
Suppression of erythropoiesis by dietary nitrate. Ashmore T, Fernandez BO, Evans CE, Huang Y, Branco-Price C, Griffin JL, Johnson RS, Feelisch M, Murray AJ. FASEB J. 2015 Mar;29(3):1102-12.
Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. Horscroft JA, Burgess SL, Hu Y, Murray AJ. PLoS One. 2015 Sep 21;10(9):e0138564.
Metabolic differentiation in the embryonic retina. Agathocleous M, Love NK, Randlett O, Harris JJ, Liu J, Murray AJ, Harris WA. Nat Cell Biol. 2012 Aug;14(8):859-64.
Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest. Levett DZ, Radford EJ, Menassa DA, Graber EF, Morash AJ, Hoppeler H, Clarke K, Martin DS, Ferguson-Smith AC, Montgomery HE, Grocott MP, Murray AJ; Caudwell Xtreme Everest Research Group. FASEB J. 2012 Apr;26(4):1431-41.
Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. Murray AJ, Knight NS, Cochlin LE, McAleese S, Deacon RM, Rawlins JN, Clarke K. FASEB J. 2009 Dec;23(12):4353-60.
Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. Murray AJ, Cole MA, Lygate CA, Carr CA, Stuckey DJ, Little SE, Neubauer S, Clarke K. J Mol Cell Cardiol. 2008 Apr;44(4):694-700.
Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart. Murray AJ, Lygate CA, Cole MA, Carr CA, Radda GK, Neubauer S, Clarke K. Cardiovasc Res. 2006 Jul 1;71(1):149-57.
Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. Murray AJ, Panagia M, Hauton D, Gibbons GF, Clarke K. Diabetes. 2005 Dec;54(12):3496-502.
Uncoupling proteins in human heart. Murray AJ, Anderson RE, Watson GC, Radda GK, Clarke K. Lancet. 2004 Nov 13-19;364(9447):1786-8.
