Publications
Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G and Smith KGC (2017). “Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.” J Exp Med. 214(4):1111-1128. doi: 10.1084/jem.20161382
Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA; UK IBD Genetics Consortium., Traherne JA, Lyons PA, Parkes M and Smith KGC (2017). “Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.” Nat Genet. 49(2):262-268. doi: 10.1038/ng.3755
Peters JE, Lyons PA, Lee JC, Richard AC, Fortune MD, Newcombe PJ, Richardson S and Smith KGC (2016). “Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune-mediated disease.” PLoS Genet.12(3):e1005908. doi: 10.1371/journal.pgen.1005908
McKinney EF, Lee, JC, Jayne DRW, Lyons PA and Smith KGC (2015). T cell exhaustion, costimulation and clinical outcome in autoimmunity and infection. Nature 523(7562): 612-616. doi: 10.1038/nature14468.
Linterman, MA, Denton, AE, Divekar, DP, Zvetkova, I, Kane, L, Ferreira, C, Veldhoen, M, Clare, S, Dougan G, Espéli, M, and Smith, KGC(2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. ELIFE, 3. doi:10.7554/eLife.03180
LeeJC, EspéliM, AndersonCA, LintermanMA, PocockJM, WilliamsNJ, RobertsR, ViatteS, FuB, PeshuN, Tran TH, Nguyen HP, WesleyE, EdwardsC, AhmadT, MansfieldJC, GearryR, DunstanS, Williams TS, BartonA, VinuesaCG, UK IBD Genetics Consortium, ParkesM, LyonsPA, SmithKGC. Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell 2013: 155(1):57-69.
Marion Espéli, Menna R. Clatworthy, Susanne Bökers, Kate E. Lawlor, Antony J. Cutler, Frank Köntgen, Paul A. Lyons, Kenneth G. C. Smith. Analysis of a wild mouse Fcgr2b promoter variant reveals a novel role for FcgRIIb in the control of the germinal center and autoimmunity. J Exp Med, 2012 Nov 19;209(12):2307-19.
McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DRW, Willcocks LC, Koukoulaki M, Hatton A, MacAry PA, Brazma A, Chaudhry AN and Smith KGC. A CD8 memory T cell transcription signature predicts prognosis in autoimmune diseases. Nature Medicine, 2010; in press. Nat Med 16(5): 586-591, 581p following 591.