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Cambridge Cardiovascular


Department of Pharmacology

The Department of Pharmacology is looking to appoint a talented PhD student to develop an ex vivo model of arterial thrombosis. This Studentship is funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), in partnership with the British Heart Foundation.

Cardiovascular disease is a major cause of death in the UK. Thrombosis is the major acute event that triggers a heart attack or stroke. Development of new anti-thrombotic drugs is therefore vital, and the starting point for this process is a better understanding of the molecular regulation of thrombosis.

Thrombosis is a complex, multicellular process. The in vivo carotid artery injury model in anaesthetised mice is extensively used to investigate thrombus formation. Reduction in the number of mice used in these experiments to the minimum possible is an ethical imperative. In this project a humanised ex vivo carotid artery injury model will be developed that retains the benefits of the in vivo model but requires fewer animals and is more relevant to human disease.

This project will be based in the lab of Dr Matthew Harper (, Department of Pharmacology. The studentship will begin in October 2016.

Funding: Full funding covering the University Composition Fee and Maintenance (at the RCUK level), is provided for eligible candidates for up to 3 years, with effect from 1st October 2016.

Applications: Applicants should send a covering letter (1 A4 side max) and C.V. (2 A4 pages max) to Dr Matthew Harper ( Applicants should have or shortly expect to obtain a minimum of a UK II.i Honours Degree (or equivalent) in Pharmacology or a related subject including Cellular or Molecular Biology and Biochemistry. Competition is intense and successful applicants are likely to demonstrate high academic achievements. We are looking for a highly motivated, enthusiastic individual, capable of thinking and working independently.

Eligibility: This PhD position is open to UK nationals. EU nationals, who have spent at least 3 years prior to the application resident in the UK, are also eligible to apply.

Further details of eligibility criteria can be found at here (sections 7-10).

Please confirm your eligibility in your application.

Please quote reference PL07912 on your application and in any correspondence about this vacancy.

The application closing date is the 31st January 2016.

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