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Post-Doctoral Research Associate in Cardiovascular Regenerative Medicine and Bioinformatics

WT-MRC Cambridge Stem Cell Institute

Applications are invited to join Dr Sanjay Sinha’s team at the Cambridge Stem Cell Institute. We have pioneered the generation of vascular smooth muscle cells from human embryonic and induced pluripotent stem cells (iPSCs) via different embryonic lineages (Cheung et al., Nature Biotechnology 2012;30:165-73, Iyer et al., Development 2015;142:1528-41). Recently we used this approach to establish an in vitro model of vascular disease in Marfan syndrome using patient-derived iPSCs (Granata et al., Nature Genetics 2017;49:97-109).

The focus of this exciting disease oriented project will be to identify how embryonic lineage contributes to aortic disease and to develop further iPSC based models of aortic aneurysms (Ehlers-Danlos syndrome and ACTA2). The successful applicant will also work with Dr Paul Bertone for in depth bioinformatics analyses of these in vitro models (RNA-seq & ChIP-seq).

The advertised position is funded through a British Heart Foundation Program Grant for 5 years, thus allowing a highly motivated scientist to make a substantial contribution to the development of new treatments for aortic diseases and establish a career in cardiovascular regenerative medicine.

You will have a PhD with an extensive background in cell and molecular biology, experience with bioinformatics and a strong publication record. It is essential that you have excellent communication, writing and organisational skills and the ability to work collaboratively. Experience with human ES/iPS cells will be advantageous. Informal enquiries to Dr Sanjay Sinha (ss661@cam.ac.uk) are encouraged. Please apply through the University's application system here:

http://www.jobs.cam.ac.uk/job/14894/

Fixed term: The position is available from 1st Nov 2017 until 31st Oct 2022.

Only short-listed candidates will be contacted. Closing date: 2nd October 2017.

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