skip to content

Cambridge Cardiovascular

 

Dr Sanjay Sinha's team has created a blood vessel model of Marfan syndrome from human skin samples. The samples were obtained from two patients, and were first re-programmed into induced pluripotent stem cells (iPSC). Next, the samples were differentiated into smooth muscle cell lines that faithfully mimicked tissues found in human blood vessels.

Marfan syndrome is caused by mutations in a gene known as fibrillin-1 and affects ~13,000 individuals in the UK. Patients with Marfan syndrome often go on to have a thoracic aortic aneurysm (TAA) where the main artery leading away from the heart balloons and can cause a life-threatening rupture. Currently the only treatment that prevents aortic rupture for Marfan patients suffering from a TAA is to have open-heart surgery to replace the damaged section of the aorta.

Dr Sinha's team have now used these blood vessel models to improve our understanding of how the inherited disease can lead to fatal aneurysms. Their results provide insights into why clinical trials of drugs to treat the disease have so far been largely unsuccessful. The team now hope to use the lab-generated blood vessel tissues to test drugs for patients with Marfan syndrome.

This study was partially funded by the BHF Oxbridge Centre of Regenerative Medicine.

More information about the research can be found on the BHF website and in the original paper that was published in Nature Genetics.

Cambridge Cardiovascular logo - transparent

We connect cardiovascular researchers in Cambridge and beyond.

For inquiries about our research, please contact Dr Jane Sugars

For enquiries about our website or joining Cambridge Cardiovascular, please contact Denise Hatherly

Find us on LinkedIn

 

Follow us on X

Please follow us here on X for local news about research, events, funding calls, and open positions.

You must be logged into X to see our feed here:

Our Newsletter

Click on the image below for previous Newsletters and for our Email sign up form

 

Find us on YouTube