News

Improved imaging of vascular inflammation: CHAI and VISION studies

3 April 2017

Dr James Rudd , Dr Elizabeth Warburton , Dr Anthony Davenport , and others have published two studies on the imaging of vascular inflammation. The first study - CHAI - was funded by the British Heart Foundation and supported by the NIHR Cambridge BRC . CHAI study is the first prospective human study to quantify hypoxia in...

Therapeutic role for apelin receptor agonist in pulmonary arterial hypertension

27 March 2017

Teams of Dr Anthony Davenport , Dr Janet Maguire , Prof Nick Morrell , and Prof Robert Glen have identified the Elabela/Toddler (ELA) peptide in the human cardiovascular system. This peptide was first discovered in the zebrafish where it was found to have a vital role in the early cardiac development. The new study shows...

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

21 March 2017

Dr Marloes Tijssen , Dr Ernest Turro , Prof Willem Ouwehand , and collaborators from Australia, France, and UK have discovered that mutations in the gene encoding tropomyosin 4 (TPM4) cause macrothrombocytopenia in humans. Platelets are anuclear cells produced by large precursor cells called megakaryocytes. Platelets are...

TNF-alpha promotes pulmonary hypertension by suppressing BMPR-II

16 January 2017

Professor Nick Morrell , Dr Paul Upton, Dr Amer Rana , and others have identified a novel pathway for the treatment of pulmonary arterial hypertension (PAH) - a debilitating illness that affects the blood vessels in the lungs and often leads to death from heart failure. Mutations in the BMPR2 gene encoding the bone...

Enhanced CRISPR to study health and disease in all cell types

16 December 2016

Professor Ludovic Vallier , Dr Alessandro Bertero , and others from the University of Cambridge and Wellcome Trust Sanger Institute have developed a more efficient and inducible way of editing genes using CRISPR. Their single-step system is freely available and works in every cell of the body and at every stage of...

Recreating Marfan syndrome in a dish

29 November 2016

Dr Sanjay Sinha 's team has created a blood vessel model of Marfan syndrome from human skin samples. The samples were obtained from two patients, and were first re-programmed into induced pluripotent stem cells (iPSC). Next, the samples were differentiated into smooth muscle cell lines that faithfully mimicked tissues...

Epigenetic studies provide a BLUEPRINT for blood cells

22 November 2016

Cambridge researchers have led several studies looking at how epigenetic modifications affect blood and immune cells, and how this can lead to disease. The studies are part of BLUEPRINT , a large-scale research project aiming to further the understanding of how genes are activated or repressed in both healthy and diseased...

German Research Foundation (DFG) Fellowship to support platelet research

30 August 2016

Dr Annett M ü ller has been awarded a 2-year Research Fellowship by the Deutsche Forschungsgemeinschaft (DFG - German Research Foundation) to study platelets in Dr Cedric Ghevaert 's team in collaboration with Dr Thomas Krieg and Dr David A Wilcox (Medical College of Wisconsin, Milwaukee, USA). Each year in UK, >250,000...

£1M BHF Programme Grant to support research on vascular inflammation

24 August 2016

The BHF has awarded Dr Murray Clarke his first Programme Grant on "Novel mechanisms that induce vascular inflammation" (£966,437). The research aims to understand processes that cause inflammation, which worsens heart and other diseases. Cells that die in blood vessels are usually eaten by other cells. However, when dead...

Obesity is linked to premature death with gender-specific effect

15 July 2016

A study of 3.9 million adults published this week in The Lancet finds that being overweight or obese is associated with an increased risk of premature death. The risks of coronary heart disease, stroke, respiratory disease and cancer are all increased. Overall, the excess risk of premature death (before age 70) among those...

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Improved imaging of vascular inflammation: CHAI and VISION studies

Therapeutic role for apelin receptor agonist in pulmonary arterial hypertension

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

TNF-alpha promotes pulmonary hypertension by suppressing BMPR-II

Enhanced CRISPR to study health and disease in all cell types

Recreating Marfan syndrome in a dish

Epigenetic studies provide a BLUEPRINT for blood cells

German Research Foundation (DFG) Fellowship to support platelet research

£1M BHF Programme Grant to support research on vascular inflammation

Obesity is linked to premature death with gender-specific effect

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