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Cambridge BHF Centre of Research Excellence (2014-2019) has awarded nearly £900,000 to support innovative ideas through pump-priming. The funds help our researchers produce preliminary data before they submit a project grant application to an external funding body.

Our current award holders (22 projects) are listed below.

Name Title Award Year
Dr Kevin O'Shaughnessy, Prof Dario Alessi, Dr Thimo Kurz Transient site-specific knockdown of cullin-3 in vivo using LNA (Locked Nucleic Acid) antisense oligonucleotide gapmers: an alternative to conventional genetically modified mice for validating therapeutic targets? £47,750 2014
Dr Cedric Ghevaert In vitro -derived platelets: the route to universal blood products, enhanced haemostasis and targeted delivery for cardiac repair £49,385 2014
Dr Angela Wood, Prof Ian Wilkinson, Dr Rupert Payne, Ms Clare Oliver-Williams, Prof Gordon Smith Long-term maternal cardiovascular events after gestational hypertension £49,813 2014
Dr Adam Butterworth, Dr Joanna Howson, Dr Daniel Gaffney, Prof Ziad Mallat, Prof Willem Ouwehand Characterisation of transcriptional and phenotypic changes triggered by uptake of modified LD lipoprotein using macrophages derived from human iPS cells £47,443 2014
Prof Ziad Mallat, Dr Joseph Cheriyan, Prof Ian Wilkinson, Dr David Dutka Low dose IL-2 in patients with acute coronary syndromes £49,352 2014
Dr Thomas Krieg, Prof Kevin Brindle, Dr Michael Murphy In vivo observation of ROS production during re-perfusion following ischaemia using hyperpolarised 13C-dimethylsuccinate £43,293 2014
Dr Unni Krishnan, Prof Martin Bennett, Prof Willem Ouwehand, Prof Nilesh Samani

Pro-inflammatory role of monocytes in determining genetic risk in atherosclerosis


Dr Adam Butterworth, Prof John Danesh, Dr Jeffrey Barrett, Dr Ewan Birney

Causal evaluation of multiple different biological pathways in cardiovascular diseases: creation and use of an extensive toolkit to inform medicines development


Dr Murray Clarke, Prof Richard Farndale

Interleukin-1α is Directly Activated by Thrombin Cleavage During Haemostasis


Dr Zhongzhao Teng, Dr James Rudd, Prof Jonathan Gillard

Combination of biomechanical analysis and FDG PET/CT imaging in assessing aortic aneurysm progression


Dr Sanjay Sinha Prof Annemieke Aartsma-Rus, Prof Cay Kielty

Development of a novel exon skipping therapeutic strategy to treat Marfan syndrome


Dr Colin Evans, Prof Randall Johnson, Prof Alberto Smith

Thrombus formation and endothelial hypoxia-inducible factors


Dr Angela Wood, Mr Eric Harshfield, Mr Richard Houghton, Dr Adam Butterworth, Prof John Danesh, Dr Albert Coulman, Dr Julian Griffin

Towards comprehensive metabolomics coverage for cardiovascular disease


Dr Emanuele Di Angelantonio, Dr Rajiv Chowdhury, Prof John Danesh, Dr Sylvaine Bruggraber, Dr Jonathan Powell

Arsenic and risk of myocardial infarction: comparison of biological samples to assess exposure


Dr Joseph Cheriyan, Dr Michalis Kostapanos, Dr Fraz Mir, Prof Ian Wilkinson, Dr Kaisa Maki-Petaja

REVEAL-Vasc: clinical effects of anacetrapib among people with established vascular disease


Dr Amer Rana, Prof Nicholas Morrell, Dr Stefan Gräf, Dr Andrew Bannister, Prof Tony Kouzarides

A multidisciplinary approach to mapping the transcriptomic and epigenomic changes responsible for the establishment and progression of PAH


Prof Andrew Lever, Dr Jing Zhao, Dr Kourosh Saeb-Parsy, Prof Nicholas Morrell

Investigating dynamic adhesion and vascular function of late outgrowth endothelial progenitor cells in ex vivo allograft vasculature


Dr Dirk Paul, Dr Joanna Howson, Dr Adam Butterworth, Prof John Danesh, Dr Kate Downes, Prof Willem Ouwehand, Dr Carmel McEniery, Prof Ian Wilkinson, Dr Trevor Baglin

Functional analysis of the PROCR gene locus associated with CVD and their risk factors using a genotype-selectable human bioresource


Dr Dirk Paul, Dr Anthony Davenport, Dr Janet Maguire, Dr Joanna Howson, Dr Adam Butterworth, Prof John Danesh, Prof Ian Wilkinson, Dr Carmel McEniery

Genotype-based recall study to elucidate a genetic signal with coronary disease at the Endothelin Receptor A locus


Prof Ian Wilkinson, Dr Kaisa Mäki-Petäjä, Dr James Rudd, Dr Frank Waldron-Lynch, Dr John Buscombe

Novel T-cell specific PET ligand for arterial imaging


Prof Antonio Vidal-Puig, Dr Subhankar Mukhopadhyay

Modelling adipocyte-macrophage interactions using human iPS cells to develop macrophage targeted strategies to prevent obesity associated inflammatory metabolic complications


Dr Helle Jørgensen

Comparing heterogeneity in VSCMs from healthy vessels with that observed after in vivo induction of phenotypic switching



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