Cambridge BHF Centre of Research Excellence (2014-2019) has awarded nearly £900,000 to support innovative ideas through pump-priming. The funds help our researchers produce preliminary data before they submit a project grant application to an external funding body.
Our current award holders (22 projects) are listed below.
| Name | Title | Award | Year |
|---|---|---|---|
| Dr Kevin O'Shaughnessy, Prof Dario Alessi, Dr Thimo Kurz | Transient site-specific knockdown of cullin-3 in vivo using LNA (Locked Nucleic Acid) antisense oligonucleotide gapmers: an alternative to conventional genetically modified mice for validating therapeutic targets? | £47,750 | 2014 |
| Dr Cedric Ghevaert | In vitro -derived platelets: the route to universal blood products, enhanced haemostasis and targeted delivery for cardiac repair | £49,385 | 2014 |
| Dr Angela Wood, Prof Ian Wilkinson, Dr Rupert Payne, Ms Clare Oliver-Williams, Prof Gordon Smith | Long-term maternal cardiovascular events after gestational hypertension | £49,813 | 2014 |
| Dr Adam Butterworth, Dr Joanna Howson, Dr Daniel Gaffney, Prof Ziad Mallat, Prof Willem Ouwehand | Characterisation of transcriptional and phenotypic changes triggered by uptake of modified LD lipoprotein using macrophages derived from human iPS cells | £47,443 | 2014 |
| Prof Ziad Mallat, Dr Joseph Cheriyan, Prof Ian Wilkinson, Dr David Dutka | Low dose IL-2 in patients with acute coronary syndromes | £49,352 | 2014 |
| Dr Thomas Krieg, Prof Kevin Brindle, Dr Michael Murphy | In vivo observation of ROS production during re-perfusion following ischaemia using hyperpolarised 13C-dimethylsuccinate | £43,293 | 2014 |
| Dr Unni Krishnan, Prof Martin Bennett, Prof Willem Ouwehand, Prof Nilesh Samani |
Pro-inflammatory role of monocytes in determining genetic risk in atherosclerosis |
£31,524 |
2014 |
| Dr Adam Butterworth, Prof John Danesh, Dr Jeffrey Barrett, Dr Ewan Birney |
Causal evaluation of multiple different biological pathways in cardiovascular diseases: creation and use of an extensive toolkit to inform medicines development |
£50,000 |
2014 |
| Dr Murray Clarke, Prof Richard Farndale |
Interleukin-1α is Directly Activated by Thrombin Cleavage During Haemostasis |
£25,988 |
2015 |
| Dr Zhongzhao Teng, Dr James Rudd, Prof Jonathan Gillard |
Combination of biomechanical analysis and FDG PET/CT imaging in assessing aortic aneurysm progression |
£25,458 |
2015 |
| Dr Sanjay Sinha, Prof Annemieke Aartsma-Rus, Prof Cay Kielty |
Development of a novel exon skipping therapeutic strategy to treat Marfan syndrome |
£50,000 |
2015 |
| Dr Colin Evans, Prof Randall Johnson, Prof Alberto Smith |
Thrombus formation and endothelial hypoxia-inducible factors |
£30,000 |
2015 |
| Dr Angela Wood, Mr Eric Harshfield, Mr Richard Houghton, Dr Adam Butterworth, Prof John Danesh, Dr Albert Coulman, Dr Julian Griffin |
Towards comprehensive metabolomics coverage for cardiovascular disease |
£49,950 |
2015 |
| Dr Emanuele Di Angelantonio, Dr Rajiv Chowdhury, Prof John Danesh, Dr Sylvaine Bruggraber, Dr Jonathan Powell |
Arsenic and risk of myocardial infarction: comparison of biological samples to assess exposure |
£49,050 |
2015 |
| Dr Joseph Cheriyan, Dr Michalis Kostapanos, Dr Fraz Mir, Prof Ian Wilkinson, Dr Kaisa Maki-Petaja |
REVEAL-Vasc: clinical effects of anacetrapib among people with established vascular disease |
£49,962 |
2015 |
| Dr Amer Rana, Prof Nicholas Morrell, Dr Stefan Gräf, Dr Andrew Bannister, Prof Tony Kouzarides |
A multidisciplinary approach to mapping the transcriptomic and epigenomic changes responsible for the establishment and progression of PAH |
£25,200 |
2016 |
| Prof Andrew Lever, Dr Jing Zhao, Dr Kourosh Saeb-Parsy, Prof Nicholas Morrell |
Investigating dynamic adhesion and vascular function of late outgrowth endothelial progenitor cells in ex vivo allograft vasculature |
£25,000 |
2016 |
| Dr Dirk Paul, Dr Joanna Howson, Dr Adam Butterworth, Prof John Danesh, Dr Kate Downes, Prof Willem Ouwehand, Dr Carmel McEniery, Prof Ian Wilkinson, Dr Trevor Baglin |
Functional analysis of the PROCR gene locus associated with CVD and their risk factors using a genotype-selectable human bioresource |
£45,000 |
2016 |
| Dr Dirk Paul, Dr Anthony Davenport, Dr Janet Maguire, Dr Joanna Howson, Dr Adam Butterworth, Prof John Danesh, Prof Ian Wilkinson, Dr Carmel McEniery |
Genotype-based recall study to elucidate a genetic signal with coronary disease at the Endothelin Receptor A locus |
£48,900 |
2016 |
| Prof Ian Wilkinson, Dr Kaisa Mäki-Petäjä, Dr James Rudd, Dr Frank Waldron-Lynch, Dr John Buscombe |
Novel T-cell specific PET ligand for arterial imaging |
£23,037 |
2016 |
| Prof Antonio Vidal-Puig, Dr Subhankar Mukhopadhyay |
Modelling adipocyte-macrophage interactions using human iPS cells to develop macrophage targeted strategies to prevent obesity associated inflammatory metabolic complications |
£50,000 |
2016 |
| Dr Helle Jørgensen |
Comparing heterogeneity in VSCMs from healthy vessels with that observed after in vivo induction of phenotypic switching |
£28,385 |
2016 |
