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Professor Kevin Brindle

Research themes


Research Interests

My research focus is on developing clinically applicable imaging methods for detecting tumour responses to treatment.


magnetic resonance imaging ; cancer ; stem cells ; regenerative medicine

Key Publications

Hyperpolarized [U-2 H, U-13 C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells. Timm KN, Hartl J, Keller MA, Hu D, Kettunen MI, Rodrigues TB, Ralser M, Brindle KM. Magn Reson Med. 2014 Dec 17.

13 C magnetic resonance spectroscopic imaging of hyperpolarized [1-13 C, U-2 H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo. Dzien P, Kettunen MI, Marco-Rius I, Serrao EM, Rodrigues TB, Larkin TJ, Timm KN, Brindle KM. Magn Reson Med. 2014 May 6.

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin. Patrick PS, Lyons SK, Rodrigues TB, Brindle KM. Mol Imaging Biol. 2014 Oct;16(5):626-34.

Late Imaging with [1-11C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET. Lewis DY, Boren J, Shaw GL, Bielik R, Ramos-Montoya A, Larkin TJ, Martins CP, Neal DE, Soloviev D, Brindle KM. J Nucl Med. 2014 Apr 28;55(7):1144-1149.

Detection of transgene expression using hyperpolarized 13 C urea and diffusion-weighted magnetic resonance spectroscopy. Patrick PS, Kettunen MI, Tee SS, Rodrigues TB, Serrao E, Timm KN, McGuire S, Brindle KM. Magn Reson Med. 2014 Apr 14.

Clinical proton MR spectroscopy in central nervous system disorders. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkáč I, Vigneron DB, Kauppinen RA; MRS Consensus Group. Radiology. 2014 Mar;270(3):658-79.

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons. Marco-Rius I, Bohndiek SE, Kettunen MI, Larkin TJ, Basharat M, Seeley C, Brindle KM. Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):182-6.

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding. Schmidt R, Laustsen C, Dumez JN, Kettunen MI, Serrao EM, Marco-Rius I, Brindle KM, Ardenkjaer-Larsen JH, Frydman L. J Magn Reson. 2014 Mar;240:8-15.

Imaging cell death. Neves AA, Brindle KM. J Nucl Med. 2014 Jan;55(1):1-4.

Dual-modality gene reporter for in vivo imaging. Patrick PS, Hammersley J, Loizou L, Kettunen MI, Rodrigues TB, Hu DE, Tee SS, Hesketh R, Lyons SK, Soloviev D, Lewis DY, Aime S, Fulton SM, Brindle KM. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):415-20.

CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells. Steuwe C, Patel II, Ul-Hasan M, Schreiner A, Boren J, Brindle KM, Reichelt S, Mahajan S. J Biophotonics. 2014 Nov;7(11-12):906-13.

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose. Rodrigues TB, Serrao EM, Kennedy BW, Hu DE, Kettunen MI, Brindle KM. Nat Med. 2014 Jan;20(1):93-7.

Versatile and enhanced tumour modelling in mice via somatic cell transduction. Rodriguez E, Mannion L, D'Santos P, Griffiths M, Arends MJ, Brindle KM, Lyons SK. J Pathol. 2014 Mar;232(4):449-57.

More publications available through PubMed.

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