CRE Flagship project
Characterisation of the genetic basis of endothelial cell transcriptional and functional variation
Research groups from University of Leicester, University of Exeter, Cambridge University and Wellcome Sanger Institute have examined the role of endothelial cells in cardiovascular diseases. We have generated genotype, RNA-Seq, ATAC-Seq, CHIP-Seq and ECIS data on over 100 endothelial cell lines. These data have been processed and utilized in several analyses including QTL, co-localisation, eCAVIAR, and Summary-data based Mendelian Randomization (SMR).
| Name | Institution |
| Mattia Frontini | University of Exeter |
| Shu Ye | University of Leicester |
| David McVey | University of Leicester |
| Charles Solomon | University of Leicester |
| Tom Webb | University of Leicester |
| Matiss Ozols | Wellcome Sanger Institute |
| Nicole Soranzo | Wellcome Sanger Institute |
| Kevin Bin Liu | University of Cambridge |
| Wei Li | University of Cambridge |
| Stephen Watt | Wellcome Sanger Institute |
| Gabriela Ivanova | Wellcome Sanger Institute |
| Nicole Staudt | Wellcome Sanger Institute |
| Stefan Gräf | University of Cambridge |
| Nick Morrell | University of Cambridge |
