The DNA Quadruplex Helix
Shankar Balasubramanian - University of Cambridge
While DNA has been thought to exist primarily as a
two-stranded double helix, there are alternative structures that can
form. Particular G-rich sequences can fold into four-stranded structures
called G-quadruplexes under physiological conditions. In this lecture, I
will present our studies to explore the existence and function of
G-quadruplexes structures in the DNA of cells and tissues in humans and
in other species. The data suggests G-quadruplexes can play important
roles in controlling transcription and cellular identity. Chemical
biology approaches have been vital to help elucidate G-quadruplexes and
provide insights into pathways for intervention that hold potential for
therapeutics.
Host: Madeline Lancaster
If you are not at the LMB and wish to attend this seminar, please contact Ann Graham agraham@mrc-lmb.cam.ac.uk.
Zoom link available to all:
https://mrc-lmb-cam-ac-uk.zoom.us/j/93702571246?pwd=I6zsi0w8N5XcKg2gu0bac58rcyTfba.1
