Read more at: Dr Elena Pavlova
Dr Elena Pavlova
My research focuses on role of glycosphingolipids in immune regulation and autoimmunity. To investigate this, I employed an inducible mouse model of Gaucher disease which prone to lymphoid tumours and autoimmune disease. I used innovative pharmaceutical inhibitors of glycosphingolipid synthesis to demonstrate that inhibition of glucosylceramide synthesis reduced lymphoproliferation and prevent myeloma/lymphoma in mouse model of Gaucher disease.