Title: Vascular inflammation imaging using somatostatin receptor PET
Background: Jason Tarkin is a Wellcome Trust Clinical Research PhD fellow at the University of Cambridge, and a Cardiology trainee at the Barts Heart Centre in London. Previously, during medical training, Dr. Tarkin has worked at Hammersmith, Royal Brompton and Harefield Hospitals. He graduated with Distinction in Medicine from St. George’s, University of London in 2008, and was awarded summa cum laude with honors in Biology from the University of New Hampshire in 2003. The aim of his PhD thesis is to evaluate novel methods for quantifying vascular inflammation in atherosclerosis using non-invasive imaging, with specific focus on somatostatin receptor positron emission tomography.
vascular imaging ; vascular biology
Tarkin JM, Dweck MR, Evans NR, Takx RA, Brown AJ, Tawakol A, Fayad ZA, Rudd JH. Imaging Atherosclerosis. Circ Res 2016;118(4):750-69
Huang Y, Teng Z, Elkhawad M, Tarkin JM, Joshi N, Boyle JR, Buscombe JR, Fryer TD, Zhang Y, Park AY, Wilkinson IB, Newby DE, Gillard JH, Rudd JHF. High structural stress and presence of intraluminal thrombus predict abdominal aortic aneurysm 18F-FDG uptake: insights from biomechanics. Circ Cardiovasc Imag 2016; 9:e004656
Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA. Non-Invasive Molecular Imaging of Disease Activity in Atherosclerosis. Circ Res 2016;119(2):330-40
Tarkin JM, Kaski JC. Vasodilator therapy: nitrates and nicorandil. Cardiovasc Drugs and Ther 2016; 30: 367
Echavarria-Pinto M, Petraco R, van de Hoef TP, Gonzalo N, Nijjer S, Tarkin JM, Ibañez B, Sen S, Jimenez-Quevedo P, Nuñez-Gil IJ, Nombela-Franco L, Alfonso F, Fernández-Ortiz A, Piek JJ, Davies J, Escaned J. Fractional flow reserve and minimum Pd/Pa ratio during intravenous adenosine infusion: similar but not always the same. Eurointervention 2016;11(9):1013-9
Tarkin J, Malhotra A, Apps A, Di Mario C, Smith R, Rogers P, Banya W, Lane R, Kabir T, Mason M, Ilsley C, Whitbread M, Dalby M. Inter-hospital transfer for primary angioplasty: delays are due to diagnostic uncertainty rather than systems failure and universal time metrics may not be appropriate. Eurointervention 2015;11(5):511-7
Tarkin JM, Joshi F, Rudd JHF. PET Imaging of Inflammation in Atherosclerosis. Nat Rev Cardiol 2014;11(8):443-57
Echavarría-Pinto M, Gonzalo N, Ibañez B, Petraco R, Jimenez-Quevedo P, Sen S, Nijjer S, Tarkin J, Alfonso F, Nuñez-Gil IJ, Bañuelos C, Fernández-Ortiz A, Macaya C, Davies J, Koo B-K, Escaned J. Low coronary microcirculatory resistance associated to profound hypotension during intravenous adenosine infusion. Implications for the functional assessment of coronary stenoses. Circ cardiovasc intervent 2014; 7(1):35-42.
Tarkin JM, Nijjer S, Sen S, Petraco R, EchavarriaPinto M, Asress KN, Lockie T, Khawaja MZ, Mayet J, Hughes AD, Malik IS, Mikhail GW, Christopher S. Baker CS, Foale RA, Redwood S, Francis DP, Escaned J, Davies JE. Hemodynamic response to intravenous adenosine and its effect for fractional flow reserve assessment: Results of the AFFECTS (Adenosine For the Functional Evaluation of Coronary sTenosis Severity) study. Circ Cardiovasc Intervent 2013; 6(6):654-61.
Tarkin JM, Kaski JC. Pharmacological treatment of chronic stable angina pectoris. Clin Med 2013; 3 (1):63-70
Sen S, Escaned J, Malik IS, Mikhail GW, Foale RA, Mila R, Tarkin J, Petraco R, Broyd C, Jabbour R, Sethi A, Baker CS, Bellamy M, Al-Bustami M, Hackett D, Khan M, Lefroy D, Parker KH, Hughes AH, Francis DP, Di Mario C, Mayet J, Davies JE. Development and validation of a new adenosine-independent index of stenosis severity from coronary wave intensity analysis: Results of the ADVISE (Adenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll of Cardiol 2011; 10;59(15):1392-402.
Tarkin JM, Khetyar M, Kaski JC. Management of Tako-tsubo Syndrome. Cardiovasc Drugs and Ther 2008; 22(1): 71-77.