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Cambridge Cardiovascular

 

Lois is a Senior Research Associate in the Cardiovascular Epidemiology Unit in the Dept of Public Health and Primary Care. Her research interests include application of simulation modelling methods to provide evidence for policy in a range of applications, including CVD screening and management, AAA screening and intervention, and blood donation. Her work focusses on the evaluation of stratified and personalised policies around timing and frequency of screening and intervention, which offer opportunities to optimise outcomes for patients and cost-effectiveness.

Recent work has included evaluation of personalised recall intervals for blood donation, the potential use of polygenic risk scores to inform screening for AAA, and the long-term impact of COVID on AAA services.

Biography

Lois holds a BSc Biochemistry from the University of York, MSc Medical Statistics from LSHTM and PhD from the University of Cambridge. Her early work and PhD at the MRC Biostatistics Unit formed the base of evidence for the effectiveness and cost-effectiveness of screening for abdominal aortic aneurysm (AAA), informing the current UK national screening programme. She subsequently worked as a lecturer at LSHTM, teaching survival analysis and statistics in epidemiology alongside research in CVD, CKD and dementia. She is currently a Senior Research Associated based in the Cardiovascular Epidemiology Unit and affiliated to the Blood and Transplant Research Unit (BTRU) in Blood Donor Health and Behaviour, in the Department of Public Health and Primary Care at the University of Cambridge.

Research

Simulation modelling | Decision analystic modelling | Health policy | Economic Evaluation | Electronic health records | Cardiovascular disease | Aneurysms | Blood donation

Publications

Key publications: 
  1. Qi H, Wood AM, Roberts D, Di Angelantonio E, Kim LG. Stratified post-donation testing in whole blood donation in England: a modelling study based on STRIDES. Transfusion 2025. doi.org/10.1111/trf.18165
  2. Wu Y, Qi H, Wood AM, Di Angelantonio E, Kim LG. Risk factors for blood-donation-related vasovagal reactions: a systematic review and meta-analysis. Transfusion 2024. doi.org/10.1111/trf.18078
  3. Ardission M, Paraboschi EM, Lambert SA, Kim LG, et al. Genomic prediction of recurrent cardiovascular events after early-onset myocardial infarction. Circ Genom Precis Med 2024. doi.org/10.1161/CIRCGEN.124.004687
  4. Kelemen M, Wood AM, Di Angelantonio E, Sweeting M, Pennells L, Danesh J, Harrison S, Kim LG. Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm. Nature Comms 2024. doi.org/10.1038/s41467-024-52452-w
  5. Xu Z, Kaptoge S, Pennells L, Chung R, Cezard G, Arnold M, Kim LG, Di Angelantonio E, Wood AW. Age- and sex- specific thresholds for cardiovascular disease risk stratification and clinical decision-making. BMJ Medicine 2024. doi.org/10.1136/bmjmed-2023-000633
  6. Chung R, Xu Z, Arnold M, Stevens D, Keogh R, Barrett J, Harrison H, Pennells L, Kim LG, Di Angelantonio E, Paige E, Usher-Smith JA, Wood AM. Prioritising cardiovascular disease risk assessment to high risk individuals based on primary care records. PLOS One 2023. doi.org/10.1371/journal.pone.0292240
  7. Chung R, Xu Z, Arnold M, Ip S, Harrison H, Barrett J, Pennells L, Kim LG, et al. Using polygenic risk scores for prioritising individuals at greatest need of a CVD risk assessment. J Am Heart Assoc 2023. doi.org/10.1161/JAHA.122.029296
  8. Kim LG, Bolton T, Sweeting MJ, Bell S, Fahle S, McMahon A, Walker M, Ferguson E, Masser B, Milfin G, Roberts D, Di Angelantonio E, Wood AM. Impact of a post-donation haemoglobin testing strategy on efficiency and safety of whole blood donation in England: a modelling study. Transfusion 2023. doi: 10.1111/trf.17277
  9. Spacirova Z, Epstein D, Kaptoge S, Garcia Mochon L, Kim LG, et al. The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease. Eur J Health Ec 2022. doi: 10.1007/s10198-022-01533-y
  10. Kim LG, Sweeting MJ, Armer M, Jacomelli J, Nasim A, Harrison SC. Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic. PLoS ONE 2021. doi: 10.1371/journal.pone.0253327
  11. Kim LG, Boxall N, George A, Burling K, Archer P, Anning J, McCracken S, Page T, Gnanapragasam VJ. Clinical utility and cost modelling of the PHI test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to Refine MRI) multi-centre study. BMC Medicine 2020. doi: 10.1186/s12916-020-01548-3
  12. Kim LG, Wilson ECF, Davison JW, Clark AB, Myint PK, Potter JF. Self-monitoring and management of blood pressure in stroke and TIA patients: an economic evaluation of TEST-BP, a randomised controlled trial. Pharmacoecon Open 2020. doi: 10.1007/s41669-020-00196-w
  13. Kim LG, Sweeting MJ, Epstein D, Venermo M, Rohloffs FEV, Greenhalgh RM. Optimising surveillance and re-intervention strategy following elective endovascular repair of abdominal aortic aneurysm. Ann Surg 2019. doi: 10.1097/SLA.0000000000003625

Teaching and Supervisions

Research supervision: 

Lois supervises/has supervised a number of MPhil students, PhD students and postdocs. 

Senior Research Associate
Lois Kim

Affiliations