Dr Daniel Freitag

  • Postdoctoral Research Associate in Functional Genetics

Contact

Connect

Research

My research focuses on understanding the role of inflammation in the aetiology of coronary heart disease. There is substantial evidence that inflammation plays an important role in the development of coronary heart disease. Identification of the culprit factors driving misguided inflammation in coronary heart disease is key to developing novel therapeutic strategies, in order to extend the current standard of care beyond that of cholesterol and blood pressure lowering medications.

Genome-wide association studies of coronary heart disease have identified several genetic loci with suspected role in inflammation. I use large-scale genetic studies with information on inflammatory biomarkers (e.g. the INTERVAL study) and cellular phenotyping in order to elucidate the biological mechanism of genetic variants associated with coronary heart disease, as exemplified by my work on the interleukin-6 receptor.

Collaborators

  1. Professor Adam Butterworth

    Professor Adam Butterworth

    • Professor of Molecular Epidemiology
  2. Professor John Danesh

    Professor John Danesh

    • BHF Professor of Epidemiology and Medicine
  3. Professor Willem Ouwehand

    Professor Willem Ouwehand

    • Emeritus Professor of Experimental Haematology, Director of Research
  4. Professor Ziad Mallat

    Professor Ziad Mallat

    • BHF Professor of Cardiovascular Medicine