Professor Bertie Göttgens

  • Professor of Molecular Haematology
  • Director of the Wellcome-MRC Cambridge Stem Cell Institute
Professor Bertie Göttgens

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Research

Transcriptional Regulation of Blood Stem cells

My group uses a combination of experimental and computational approaches to study how transcription factor networks control the function of blood stem cells and how mutations that perturb such networks cause leukaemia. This integrated approach has resulted in the discovery of new combinatorial interactions between key blood stem cell regulators, as well as experimentally validated computational models for blood stem cells.

Current research focuses on

  1. single cell genomics of early cardiovascular development
  2. computer models to chart the transcriptional landscape of blood stem and progenitor cell differentiation
  3. transcriptional consequences of leukaemogenic mutations in leukaemia stem/progenitor cells
  4. molecular characterisation of human blood stem/progenitor cell populations used in cell and gene therapy protocols.

Collaborators

  1. Dr Cedric Ghevaert

    Dr Cedric Ghevaert

    • Professor of Transfusion Medicine
  2. Professor Benjamin Simons

    Professor Benjamin Simons

    • Herchel Smith Chair in Physics
  3. Professor Sanjay Sinha

    Professor Sanjay Sinha

    • Professor in Cardiovascular Regenerative Medicine