Biography
Clinically, I work in advanced failure and cardiac transplantation at one of the UK’s renowned centres, Royal Papworth Hospital NHS Trust.
My research looks into the heart’s metabolism using magnetic resonance spectroscopy techniques to peer into the chemical reactions taking place inside the human heart, taking place in Oxford and Cambridge Universities.
I run clinical and MRI based studies on heart failure in Cambridge and I'm currently working on setting up a magnetic resonance spectroscopy research service based in Royal Papworth Hospital as a platform for studies.
Research
Heart failure, cardiac metabolism, magnetic resonance spectroscopy, cardiac magnetic resonance, mitochondrial biology
Publications
Scientific Publications
*Retained Metabolic Flexibility of the Failing Human Heart. William D Watson, Peregrine G Green, Andrew JM Lewis, Per Arvidsson, Giovanni Luigi De Maria, Håkan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovič, Stefan Neubauer, Neil Herring, Oliver J. Rider (2023). Circulation, 148: 109-123.
*Right ventricular-pulmonary arterial uncoupling and ventricular-secondary mitral regurgitation: Relationship with outcomes in advanced heart failure. Watson, W.D., Burrage, M.K., Ong, L.P., Bhagra, S., Garbi, M. and Pettit, S., 2024. JHLT Open, 4, p.100080.
Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction. Burrage MK, Hundertmark M, Valkovic L, Watson WD, Rayner J, Sabharwal N, Ferreira VM, Neubauer S, Rider OJ, Lewis AJM (2021). Circulation, 133, 1664-1678.
*Myocardial Energy Response to Glyceryl Trinitrate: Physiology Revisited. Watson WD, Green PG, Valkovic L, Herring N, Neubauer S, Rider OJ (2021). Frontiers in Physiology, 12, 2309.
*Nicotinic acid receptor agonists impair myocardial contractility by energy starvation. Watson WD, Timm KN, Lewis AJ, Miller JJJ, Emmanuel Y, Clarke K, Neubauer S, Tyler DJ, Rider OJ (2020). Journal of the Federation of American Societies for Experimental Biology, 34(11), 14878-14891.
Myocardial Energetics in Obesity: Enhanced ATP Delivery Through Creatine Kinase With Blunted Stress Response. Rayner JJ, Peterzan MA, Watson WD, Clarke WT, Neubauer S, Rodgers CT, Rider OJ (2020). Circulation. 2020 Apr 7;141(14):1152-1163
Localised rest and stress human cardiac creatine kinase reaction kinestics at 3 tesla. Clarke WT, Peterzan MA, Rayner JJ, Sayeed RA, Petrou M, Krasopoulos G, Lake HA, Raman B, Watson WD, Cox P, Hundertmark MJ, Apps AP, Lygate CA, Neubauer S, Rider OJ, Rogers CT. (2019) NMR in biomedicine. E4085.
Review
*A Mitochondrial Basis for Heart Failure Progression. WD Watson, PM Arvidsson, JJJ Miller, AJ Lewis and OJ Rider. Cardiovascular Drugs and Therapy (2024) 1-11.
*Use of cardiac magnetic resonance to detect changes in metabolism in heart failure. William D. Watson, Jack J. J. Miller, Andrew Lewis, Stefan Neubauer, Damian Tyler, Oliver J. Rider, Ladislav Valkovič. (2020). Cardiovascular Diagnosis and Therapy
*Pregnancy in heart transplant recipients; current perspectives. Watson WD, Bhagra SK, Bhagra CJ (2019). Transplant Research and Risk Management. 11, 29-38.
* denotes first author.
Exercise capacity following SARS-CoV-2 infection is related to changes in cardiovascular and lung function in military personnel. Chamley, R. R., Holland, J. L., Collins, J., Pierce, K., Watson, W. D., Green, P. G., ... & Rider, O. J. (2024). International Journal of Cardiology, 395, 131594.
Comparing Cardiac Mechanics and Myocardial Fibrosis in DBD and DCD Heart Transplant Recipients. Burrage MK, Cheshire C, Hey CY, Azam S, Watson WD, Bhagra S, Berman M, D'Errico L, Jenkins DP, Kaul P, Large S, Lewis C, Martinez L, Messer S, Page A, Parameshwar J, Pettit S, Rafiq M, Tsui S, Tweed K, Weir-McCall JR, Kydd A. (2022). J Card Fail 13, S1071-9164(22)01224-6
Rapid, B1-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux. Miller JJ, Valkovic L, Kerr M, Timm KN, Watson WD, Lau JYC, Tyler A, Rogers C, Bottomley PA, Heather LC, Tyler DJ (2020). Magnetic Resonance in Medicine, Magnetic Resonance in Medicine 85(6), 2978-2991.
Heritability of Haemodynamics in the Ascending Aorta. McGurk KA, Owen B, Watson WD, Nethonoda RM, Cordell HJ, Farrall M, Rider OJ, Watkins H, Revell A, Keavney BD (2020). Scientific Reports, 10, 14356
Left Atrial Function is Associated with Earlier Need for Cardiac Surgery in Moderate to Severe Mitral Regurgitation: Usefulness in Targeting for Early Surgery. Ring L, Abu-Omar Y, Kaye N, Rana BS, Watson W, Dutka DP, Vassiliou VS. (2018). Journal of the American Society of Echocardiography, S0894-7317(18)30151-2
The Prognostic Benefit of Optimum Left Ventricular Lead Position in CRT: Follow-up of the TARGET Study Cohort. Kydd A, Khan F, Watson W, Pugh P, Virdee M, Dutka D (2014). Journal of the American College of Cardiology: Heart Failure, 2(3): 205-12
Beta-blockers in cirrhosis patients with refractory ascites. A E Robins, A Bowden, W Watson, F Smith, W T Gelson, W Griffiths (2014). Hepatology. 59(5): 2054-5
Remote Ischemic Preconditioning Improves Outcome at 6 Years After Elective Percutaneous Coronary Intervention: The CRISP Stent Trial Long-Term Follow-Up. Davies WR, Brown AJ, Watson W, McCormick LM, West NE, Dutka DP, Hoole SP (2013). Circulation Cardiovascular Intervention, 1;6(3), 246-51
