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Cardiovascular & Metabolic ECR 2017

When Nov 02, 2017
from 09:00 AM to 06:00 PM
Where St Catharine's College, Cambridge
Contact Name
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This year's Early Careers Research day will take place on Thursday 2 November in the McGrath Centre, St Catharine's College, and will be a collaboration between Cardiovascular SRI & Metabolic SRN to help connect researchers in these two networks.

We welcome Profs Sue Ozanne, Steve O'Rahilly, and Khalid Naseem, and Dr Magnus Althage as our keynote speakers. Additionally, Prof Toni Vidal-Puig will give us an overview of the Cardio-Metabolic research theme in the planned Heart & Lung Research Institute (HLRI).

This year's research themes include:

  • Developmental programming in cardio-metabolic disease
  • Inflammation & platelet function in cardio-metabolic disease
  • Mechanisms of obesity & its cardio-metabolic effects
  • Translational science: From bench to bedside

The event will be open to all and will be free but we will be restricted to ~100 delegates by the venue size and we will therefore ask you to register here by 31 October 2017. Please contact Vicky Reid if you have any problems with registration.

This year's draft programme has been copied below. Previous years' Cardiovascular ECR programmes are available for 2015 and 2016. Hope to see you on 2nd November!


Cardiovascular & Metabolic Early Careers Research Day 2017

08.30-09.00  Registration and Refreshments

09.00-09.15  Prof Toni Vidal-Puig: Welcome & HLRI overview

Session 1: Developmental Programming in Cardio-Metabolic Disease

09.15-09.45  Prof Sue Ozanne: Programming by maternal overnutrition: A developing obesity crisis

09.45-09.55  H Yong: IGF2 deletion from the placental endocrine layer alters maternal sensitivity to glucose and insulin, and affects foetal and early postnatal growth in mice

09.55-10.05  R Hess: What's that smell? First evidence of cardio-protective actions of hydrogen sulphide in the developing heart

10.05-10.15  AM Spiroski: Sex-specific programming of cardiac bioenegetics by chronic hypoxic pregnancy and mitochondria-targeted antioxidant therapy

10.15-11.35  Tea & Connections: Identifying links between research areas

Session 2: Bench to Bedside

11.35-12.05  Dr Magnus Althage (AstraZeneca): From bench to bedside through translatable in vitro models

12.05-12.35  Dr Duncan Richards (GSK): Dose-dependent progressive immunotherapeutic clearance of systemic amyloid deposits by repeated doses of antibody to serum amyloid P component (SAP)

12.35-13.10  Techniques: Group discussions of research techniques

13.10-14.20  Lunch & Posters

Session 3: Platelets & Inflammation in Cardio-Metabolic Disease

14.20-14.50  Prof Khalid Naseem (Leeds): New models of platelet hyperactivity - the proinflammatory platelet

14.50-15.00  M Nus: Marginal zone B cells limit TFH differentiation in atherosclerosis in response to a high cholesterol diet

15.00-15.10  V Azzu: Is de novo lipogenesis a driver of fibrosis in non-alcoholic fatty liver disease (NAFLD)?

15.10-15.20  S Burgess: Inhibiting TMEM16F, a platelet scramblase

15.20-15.40   Tea break

Session 4: Obesity & its Cardio-Metabolic Effects

15.40-16.10  Prof Sir Stephen O Rahilly: Some observations on the causes and consequences of obesity

16.10-16.20  J Beeson: Effect of maternal exercise during obese pregnancy on the cardiovascular health of male mouse offspring

16.20-16.30  G Bidault: SREBP1c mediated de novo lipogenesis sequesters NADPH to inactivate macrophages antioxidant defences and promote their alternative activation

16.30-16.40  V Auyeung: Investigating the aetiologic links between the gut microbiota, metabolic profiles and metabolic disease

16.40-17.00  Prof Toni Vidal-Puig: Prizes & Closing words

17.00-18.00  Drinks and networking

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