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Cambridge Cardiovascular

 

Lois is a Senior Research Associate in the Cardiovascular Epidemiology Unit in the Dept of Public Health and Primary Care. Her research interests include application of simulation modelling methods to provide evidence for policy in a range of applications, including CVD screening and management, AAA screening and intervention, and blood donation. Her work focusses on the evaluation of stratified and personalised policies around timing and frequency of screening and intervention, which offer opportunities to optimise outcomes for patients and cost-effectiveness.

Recent work has included evaluation of personalised recall intervals for blood donation, the potential use of polygenic risk scores to inform screening for AAA, and the long-term impact of COVID on AAA services.

Biography

Lois graduated from the University of York in 1999 with a BSc in Biochemistry. She also holds an Msc in Medical Statistics from LSHTM (2001) and PhD from University of Cambridge (2007). Her early work and PhD at the MRC Biostatistics Unit formed the base of evidence for the effectiveness and cost-effectiveness of screening for abdominal aortic aneurysm (AAA), informing a national screening programme that commenced in the UK in 2009. She subsequently worked as a lecturer at LSHTM for ten years, teaching survival analysis and statistics in epidemiology alongside research in CVD, CKD and dementia. She returned to Cambridge in 2017 where she is a Senior Research Associated based in the Cardiovascular Epidemiology Unit and affiliated to the Blood and Transplant Research Unit (BTRU).

Publications

Key publications: 

Kelemen M, Wood AM, Di Angelantonio E, Sweeting M, Pennells L, Danesh J, Harrison S, Kim LG. Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm. 2023. https://www.medrxiv.org/content/10.1101/2023.11.02.23297906

Kim LG, Bolton T, Sweeting MJ, Bell S, Fahle S, McMahon A, Walker M, Ferguson E, Masser B, Milfin G, Roberts D, Di Angelantonio E, Wood AM. Impact of a post-donation haemoglobin testing strategy on efficiency and safety of whole blood donation in England: a modelling study. Transfusion 2023. doi: 10.1111/trf.17277

Kim LG, Sweeting MJ, Armer M, Jacomelli J, Nasim A, Harrison SC. Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic. PLoS ONE 2021. doi: 10.1371/journal.pone.0253327

Kim LG, Boxall N, George A, Burling K, Archer P, Anning J, McCracken S, Page T, Gnanapragasam VJ. Clinical utility and cost modelling of the PHI test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to Refine MRI) multi-centre study. BMC Medicine 2020. doi: 10.1186/s12916-020-01548-3

Kim LG, Wilson ECF, Davison JW, Clark AB, Myint PK, Potter JF. Self-monitoring and management of blood pressure in stroke and TIA patients: an economic evaluation of TEST-BP, a randomised controlled trial. Pharmacoecon Open 2020. doi: 10.1007/s41669-020-00196-w

Kim LG, Sweeting MJ, Epstein D, Venermo M, Rohloffs FEV, Greenhalgh RM. Optimising surveillance and re-intervention strategy following elective endovascular repair of abdominal aortic aneurysm. Ann Surg 2019. doi: 10.1097/SLA.0000000000003625

Teaching and Supervisions

Research supervision: 

Lois supervisers/has supervised a number of MPhil students, PhD students and postdocs. 

Senior Research Associate

Affiliations