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Cambridge Cardiovascular


Patrick Calvert is a Consultant Interventional Cardiologist at Royal Papworth Hospital NHS Foundation Trust specialising in coronary and structural intervention and Clinical Lead for Structural Intervention. From 2014-2016, he was a Consultant Cardiologist at the Queen Elizabeth Hospital, University Hospitals Birmingham where he was Cardiovascular Clinical Academic Group Lead.

At Royal Papworth, Dr Calvert undertakes a broad range of coronary and structural interventions. He graduated from the Universities of Cambridge and Oxford and trained in the Eastern Deanery for general and interventional cardiology. He undertook a PhD at Cambridge University investigating vulnerability in coronary plaques which resulted in several publications and prizes including the British Cardiovascular Intervention Society Young Investigators Award and the Journal of the American College of Cardiology Young Author Achievement Award (JACC Imaging).

He undertook a Fellowship in Paris in 2010 at Centre Hospitalier Universitaire Bichat. He continues his research into the vulnerable plaque and is Principle Investigator on several national database projects examining the health outcomes from coronary and structural interventions. He is on the EuroPCR Programme Committee and the TCT Scientific Committee (USA). Dr Calvert is currently the National Institute of Healthcare Research Clinical Research Network National Specialty Lead for Atherosclerosis and also Preventative Cardiovascular Diseases.

In January 2022, Dr Calvert was appointed as the Director of Research and Development at Royal Papworth Hospital.


General Cardiology: including chest pain, murmurs and valve disease, palpitation/arrhythmia, dizziness/blackout, shortness of breath, heart failure, hypertension

Coronary Intervention: assessment and treatment of coronary artery disease (stable angina and myocardial infarction) including angiography and angioplasty and stenting (PCI), pressure wire (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT)

Structutal Intervention: assessment and treatment of structural cardiac problems including valve disease and septal defects. Percutaneous valvuloplasty, percutaneous device closure of patent foramen ovale (PFO) and atrial septal defect (ASD). Percutaneous device closure for paravalvular leak and post-infarction ventricular septal defect. Percutaneous device closure of left atrial appendage for stroke prophylaxis in atrial fibrillation. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy.

Research Interests
Vulnerable Plaque Research: investigating what caused heart attacks using multi-modality imaging
National Database Research: investigating clinical outcomes of coronary and structural interventions using national databases and national collaborations.


Key publications: 

Obaid DR, Calvert PA, Bennett MR, West NEJ. High-Risk Atherosclerotic Plaque in Aberrant Circumflex Coronary Artery. J Invasive Cardiol. 2018 Mar;30(3):E26.

Hoole SP, Hernández-Sánchez J, Davies WR, McNab DC, Calvert PA, Rana BS, Shapiro LM, Davies MG. Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study. Can J Cardiol. 2017 Dec;33(12):1708-1715. doi: 10.1016/j.cjca.2017.09.005. Epub 2017 Sep 12.

Obaid DR, Calvert PA, Brown A, Gopalan D, West NEJ, Rudd JHF, Bennett MR. Coronary CT angiography features of ruptured and high-risk atherosclerotic plaques: Correlation with intra-vascular ultrasound. J Cardiovasc Comput Tomogr. 2017 Nov;11(6):455-461. doi: 10.1016/j.jcct.2017.09.001. Epub 2017 Sep 5.

Costopoulos C, Huang Y, Brown AJ, Calvert PA, Hoole SP, West NEJ, Gillard JH, Teng Z, Bennett MR. Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress. JACC Cardiovasc Imaging. 2017 Dec;10(12):1472-1483. doi: 10.1016/j.jcmg.2017.04.017. Epub 2017 Jul 19.

Chandran S, Watkins J, Abdul-Aziz A, Shafat M, Calvert PA, Bowles KM, Flather MD, Rushworth SA, Ryding AD.Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction. J Am Heart Assoc. 2017 May 3;6(5). pii: e005868. doi: 10.1161/JAHA.117.005868.

Liu X, Calvert PA, Arif S, Keane PA, Denniston AK. Patent foramen ovale presenting as visual loss. JRSM Open. 2016 Dec 1;8(1):2054270416669302. doi: 10.1177/2054270416669302. eCollection 2016 Jan.

Brown AJ, Shah ASV, West NEJ, Costopoulos C, Orzalkiewicz M, Newby DE, Bennett MR, Mills NL, Calvert PA. High-Sensitivity Troponin I Is Associated With High-Risk Plaque and MACE in Stable Coronary Artery Disease. JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt A):1200-1203. doi: 10.1016/j.jcmg.2016.09.025. Epub 2017 Jan 18. No abstract available.

Townend JN, Ludman PF, Doshi SN, Khan H, Calvert PA. Assessing flow limitation in patients with stable coronary artery disease. BMJ. 2016 Oct 20;355:i5534. doi: 10.1136/bmj.i5534. No abstract available.

Sinclair H, Veerasamy M, Bourantas C, Egred M, Nair A, Calvert PA, Brugaletta S, Mintz GS, Kunadian V. The Role of Virtual Histology Intravascular Ultrasound in the Identification of Coronary Artery Plaque Vulnerability in Acute Coronary Syndromes. Cardiol Rev. 2016 Nov/Dec;24(6):303-309. Review.

George S, DeGiovanni J, McCafferty IJ, Calvert PA. Closure of a coronary artery: coronary sinus fistula. EuroIntervention. 2016 Oct 10;12(8):e1009. doi: 10.4244/EIJV12I8A164. No abstract available.

Calvert PA, Northridge DB, Malik IS, Shapiro L, Ludman P, Qureshi SA, Mullen M, Henderson R, Turner M, Been M, Walsh KP, Casserly I, Morrison L, Walker NL, Thomson J, Spence MS, Mahadevan VS, Hoye A, MacCarthy PA, Daniels MJ, Clift P, Davies WR, Adamson PD, Morgan G, Aggarwal SK, Ismail Y, Ormerod JO, Khan HR, Chandran SS, de Giovanni J, Rana BS, Ormerod O, Hildick-Smith D. Percutaneous Device Closure of Paravalvular Leak: Combined Experience From the United Kingdom and Ireland. Circulation. 2016 Sep 27;134(13):934-44. doi: 10.1161/CIRCULATIONAHA.116.022684.

Brown AJ, Teng Z, Calvert PA, Rajani NK, Hennessy O, Nerlekar N, Obaid DR, Costopoulos C, Huang Y, Hoole SP, Goddard M, West NE, Gillard JH, Bennett MR. Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging. Circ Cardiovasc Imaging. 2016 Jun;9(6). pii: e004172. doi: 10.1161/CIRCIMAGING.115.004172.

Cruz-Gonzalez I, Rama-Merchan JC, Calvert PA, Rodríguez-Collado J, Barreiro-Pérez M, Martín-Moreiras J, Diego-Nieto A, Hildick-Smith D, Sánchez PL. Percutaneous Closure of Paravalvular Leaks: A Systematic Review.
J Interv Cardiol. 2016 Aug;29(4):382-92. doi: 10.1111/joic.12295. Epub 2016 May 31. Review.

Calvert PA, Brown AJ, Hoole SP, Obaid DR, West NE, Bennett MR. Geographical miss is associated with vulnerable plaque and increased major adverse cardiovascular events in patients with myocardial infarction. Catheter Cardiovasc Interv. 2016 Sep;88(3):340-7. doi: 10.1002/ccd.26275. Epub 2015 Nov 3.

Brown AJ, Obaid DR, Costopoulos C, Parker RA, Calvert PA, Teng Z, Hoole SP, West NE, Goddard M, Bennett MR. Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma. Circ Cardiovasc Imaging. 2015 Oct;8(10):e003487. doi: 10.1161/CIRCIMAGING.115.003487.

George S, Calvert PA.  Ischaemic heart disease - a selected review of recent developments. Curr Opin Cardiol. 2015 Nov;30(6):657-62. doi: 10.1097/HCO.0000000000000230. Review.

Rana BS, Calvert PA, Punjabi PP, Hildick-Smith D. Role of percutaneous mitral valve repair in the contemporary management of mitral regurgitation. Heart. 2015 Oct;101(19):1531-9. doi: 10.1136/heartjnl-2014-306256. Epub 2015 Jun 22. Review.

Kydd AC, McNab D, Calvert PA, Hoole SP, Rekhraj S, Sievert H, Shapiro LM, Rana BS. The Eustachian ridge: not an innocent bystander. JACC Cardiovasc Imaging. 2014 Oct;7(10):1062-3. doi: 10.1016/j.jcmg.2014.02.011. No abstract available.

Obaid DR, Calvert PA, Gopalan D, Parker RA, West NE, Goddard M, Rudd JH, Bennett MR. Dual-energy computed tomography imaging to determine atherosclerotic plaque composition: a prospective study with tissue validation. J Cardiovasc Comput Tomogr. 2014 May-Jun;8(3):230-7. doi: 10.1016/j.jcct.2014.04.007. Epub 2014 May 2.

Calvert PA, Cockburn J, Wynne D, Ludman P, Rana BS, Northridge D, Mullen MJ, Malik I, Turner M, Khogali S, Veldtman GR, Been M, Butler R, Thomson J, Byrne J, MacCarthy P, Morrison L, Shapiro LM, Bridgewater B, de Giovanni J, Hildick-Smith D. Percutaneous closure of postinfarction ventricular septal defect: in-hospital outcomes and long-term follow-up of UK experience. Circulation. 2014 Jun 10;129(23):2395-402. doi: 10.1161/CIRCULATIONAHA.113.005839. Epub 2014 Mar 25.

Teng Z, Brown AJ, Calvert PA, Parker RA, Obaid DR, Huang Y, Hoole SP, West NE, Gillard JH, Bennett MR. Coronary plaque structural stress is associated with plaque composition and subtype and higher in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous Coronary Arteries) study. Circ Cardiovasc Imaging. 2014 May;7(3):461-70. doi: 10.1161/CIRCIMAGING.113.001526. Epub 2014 Feb 20.

Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJ, Flapan AD, Uren NG, Behan MW, Cruden NL, Mills NL, Fox KA, Rudd JH, Dweck MR, Newby DE. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet. 2014 Feb 22;383(9918):705-13. doi: 10.1016/S0140-6736(13)61754-7. Epub 2013 Nov 11.

Obaid DR, Calvert PA, Gopalan D, Parker RA, Hoole SP, West NE, Goddard M, Rudd JH, Bennett MR. Atherosclerotic plaque composition and classification identified by coronary computed tomography: assessment of computed tomography-generated plaque maps compared with virtual histology intravascular ultrasound and histology. Circ Cardiovasc Imaging. 2013 Sep;6(5):655-64. doi: 10.1161/CIRCIMAGING.112.000250. Epub 2013 Aug 19.

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation. 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10.

Consultant Cardiologist
Director of Research and Development

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