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Dominika Krzyzanska

Dominika  Krzyzanska

BHF 4-year programme PhD Student

Research Interests

Title: Investigating the Role of Macrophage Polarisation and Metabolism on Interleukin-1 Expression

Abstract: Inflammation plays a fundamental role in the pathogenesis of atherosclerosis. Interleukin-1a (IL-1a) and Interleukin-1b (IL-1b) are crucial drivers of the inflammatory response and progression of atherosclerotic plaques. Macrophages are the predominant cell type which produce and secrete IL-1a and IL-1b in response to a range of stimuli. M2 polarised macrophages are known to induce anti-inflammatory responses involved in tissue remodelling and wound healing, however, preliminary work identified increased stability and more pronounced secretion of IL-1a and IL-1b upon inflammasome activation in M2 macrophages. Previous studies have suggested a link between IL-1-driven inflammation and mitochondrial dysfunction. This PhD project will investigate if M2 polarised macrophages secrete more active IL-1 and are able to activate the inflammasome a prolonged time after priming. Additionally, we will aim to identify the mechanisms linking IL-1a secretion and mitochondrial dysfunction in atherosclerosis. Further work will be performed to identify whether alterations in metabolism of M1 and M2 polarised macrophages affect stability and/or secretion of IL-1a and IL-1b.


Atherosclerosis ; metabolism ; interleukin-1 ; Inflammation ; mitochondrial dysfunction, macrophage polarisation

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