Dominika Krzyzanska

Title: Investigating Inflammatory Responses of Various Macrophage Subtypes

Abstract: Macrophages are immune cells of fundamental importance in health and disease, which can be activated into two major subtypes; pro-inflammatory M1 macrophages or anti-inflammatory and reparative M2 cells. They play a key role in multiple diseases including atherosclerosis, where aberrant activation leads to release of pro-inflammatory cytokines and activation of adaptive immunity. Moreover, plasticity of macrophages allows them to adapt and change their phenotype in response to various stimuli. My project focuses on exploring the inflammatory responses of different macrophage populations, with a focus on IL-1 expression, and the potential involvement of macrophage immunometabolism.