skip to primary navigationskip to content
 

Dominika Krzyzanska

Dominika  Krzyzanska

BHF 4-year programme PhD Student


Research Interests

Title: Investigating the Role of Macrophage Polarisation and Metabolism on Interleukin-1 Expression

Abstract: Inflammation plays a fundamental role in the pathogenesis of atherosclerosis. Interleukin-1a (IL-1a) and Interleukin-1b (IL-1b) are crucial drivers of the inflammatory response and progression of atherosclerotic plaques. Macrophages are the predominant cell type which produce and secrete IL-1a and IL-1b in response to a range of stimuli. M2 polarised macrophages are known to induce anti-inflammatory responses involved in tissue remodelling and wound healing, however, preliminary work identified increased stability and more pronounced secretion of IL-1a and IL-1b upon inflammasome activation in M2 macrophages. Previous studies have suggested a link between IL-1-driven inflammation and mitochondrial dysfunction. This PhD project will investigate if M2 polarised macrophages secrete more active IL-1 and are able to activate the inflammasome a prolonged time after priming. Additionally, we will aim to identify the mechanisms linking IL-1a secretion and mitochondrial dysfunction in atherosclerosis. Further work will be performed to identify whether alterations in metabolism of M1 and M2 polarised macrophages affect stability and/or secretion of IL-1a and IL-1b.

Keywords

Atherosclerosis ; metabolism ; interleukin-1 ; Inflammation ; mitochondrial dysfunction, macrophage polarisation

Cambridge Cardiovascular logo - transparent

Logo design by Dr Ana-Mishel Spiroski and Dr Sarah Morgan.

 

We connect cardiovascular researchers in Cambridge.

Please follow us on Twitter for local news about research, events, funding calls, and open positions.

For inquiries about our research or the website, please contact Dr Tammy Dougan