Biography
I am a post-doctoral biochemist with experience in both scientific research and product development labs. During my career (principally at the University of Cambridge) I have specialised in vascular biochemistry, collagen and platelet biology. I am experienced in a wide range of biochemical techniques and have numerous first-author publications in high-ranking scientific journals.
I also have experience in the development of new assays, protocol verification, optimization, streamlining and modernization in line with ISO 13485 where appropriate. Data monitoring, collation, organization and storage. Compilation of company scientific reports and publications. Overseeing maintenance and production procedures including sample collection, analysis and data processing. I also have experience in science communication and am a qualified phlebotomist.
Research
The interactions of matrix metalloproteinases with platelets and extracellular matrix components and subsequent effects on platelet behaviour and thrombus formation.
Publications
Howes J-M, Pugh N, Hamaia SW, Jung SM, Knäuper V, Malcor J-D, Farndale RW. MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. Res Prac Thromb Haem. 2018: 2; 370-379.
Induruwa I, Moroi M, Bonna A, Malcor J-D, Howes J-M, Warburton EA, Farndale RW, Jung SM. Platelet collagen receptor gpvi-dimer recognizes fibrinogen and fibrin through their d-domains, contributing to platelet adhesion and activation during thrombus formation. J Thromb Haemost. 2018: 16; 1-16.
Watson BR, White NA, Taylor KA, Howes J-M, Malcor JD, Bihan D, Sage SO, Farndale RW, Pugh N. Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner. Metallomics. 2016: 8; 91-100.
Howes J-M, Pugh N, Knäuper V, Farndale R. Modified platelet deposition on matrix metalloproteinase 13 digested collagen I. J Thromb Haemost. 2015: 13; 2253-9.
Howes J-M, Bihan D, Slatter DA, Hamaia SW, Packman LC, Knäuper V, Visse R, Farndale RW. The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13: SEQUENCE SPECIFICITY FOR BINDING AND CLEAVAGE. JBC. 2014: 289; 24091-101.
Howes J-M. Proteomic profiling of platelet signalling. Review. Expert Rev Proteomics. 2013: 10; 355-64.
Jung SM, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt MC, Gardiner EE, Howes J-M, Pugh N, Bihan D, Watson SP, Farndale RW. Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. JBC. 2012: 287; 30000-13.
