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Cambridge Cardiovascular



The interactions of matrix metalloproteinases with platelets and extracellular matrix components and subsequent effects on platelet behaviour and thrombus formation.


Key publications: 

Howes J-M, Pugh N, Hamaia SW, Jung SM, Knäuper V, Malcor J-D, Farndale RW. MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. Res Prac Thromb Haem. 2018: 2; 370-379.

Induruwa I, Moroi M, Bonna A, Malcor J-D, Howes J-M, Warburton EA, Farndale RW, Jung SM. Platelet collagen receptor gpvi-dimer recognizes fibrinogen and fibrin through their d-domains, contributing to platelet adhesion and activation during thrombus formation. J Thromb Haemost. 2018: 16; 1-16.

Watson BR, White NA, Taylor KA, Howes J-M, Malcor JD, Bihan D, Sage SO, Farndale RW, Pugh N. Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner. Metallomics. 2016: 8; 91-100.

Howes J-M, Pugh N, Knäuper V, Farndale R. Modified platelet deposition on matrix metalloproteinase 13 digested collagen I. J Thromb Haemost. 2015: 13; 2253-9.

Howes J-M, Bihan D, Slatter DA, Hamaia SW, Packman LC, Knäuper V, Visse R, Farndale RW. The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13: SEQUENCE SPECIFICITY FOR BINDING AND CLEAVAGE. JBC. 2014: 289; 24091-101.

Howes J-M. Proteomic profiling of platelet signalling. Review. Expert Rev Proteomics. 2013: 10; 355-64.

Jung SM, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt MC, Gardiner EE, Howes J-M, Pugh N, Bihan D, Watson SP, Farndale RW. Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. JBC. 2012: 287; 30000-13.


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