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Professor James Huntington

Keywords

haemostasis ; thrombin function ; stroke ; pulmonary embolism ; coagulation factors ; heart attack ; x-ray crystallography

Key Publications

The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization. Behrens MA, Sendall TJ, Pedersen JS, Kjeldgaard M, Huntington JA, Jensen JK. Biophys J. 2014 Oct 21;107(8):1905-12.

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis. de Diego I, Veillard F, Sztukowska MN, Guevara T, Potempa B, Pomowski A, Huntington JA, Potempa J, Gomis-Rüth FX. J Biol Chem. 2014 Nov 14;289(46):32291-302.

Homology model of human prothrombinase based on the crystal structure of Pseutarin C. Pomowski A, Ustok FI, Huntington JA. Biol Chem. 2014 Oct;395(10):1233-41.

A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop). Langdown J, Luddington RJ, Huntington JA, Baglin TP. Blood. 2014 Sep 18;124(12):1951-6.

Natural inhibitors of thrombin. Huntington JA. Thromb Haemost. 2014 Apr 1;111(4):583-9.

GpIbα interacts exclusively with exosite II of thrombin. Lechtenberg BC, Freund SM, Huntington JA. J Mol Biol. 2014 Feb 20;426(4):881-93.

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Lechtenberg BC, Murray-Rust TA, Johnson DJ, Adams TE, Krishnaswamy S, Camire RM, Huntington JA. Blood. 2013 Oct 17;122(16):2777-83.

Thrombin inhibition by the serpins. Huntington JA. J Thromb Haemost. 2013 Jun;11 Suppl 1:254-64.

An ensemble view of thrombin allostery. Lechtenberg BC, Freund SM, Huntington JA. Biol Chem. 2012 Sep;393(9):889-98.

More publications available through PubMed.