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Cambridge Cardiovascular



Key publications: 

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.     Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.    PMID: 28414328

Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response.  Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z.      Circulation. 2016 Oct 4;134(14):1039-1051. doi:   10.1161/CIRCULATIONAHA.116.022668. Epub 2016 Sep 1. PMID: 27587433

Deletion of chromosome 9p21 noncoding cardiovascular risk interval in mice alters Smad2 signaling and promotes vascular aneurysm.   Loinard C, Basatemur G, Masters L, Baker L, Harrison J, Figg N, Vilar J, Sage AP, Mallat Z.  Circ Cardiovasc Genet. 2014 Dec;7(6):799-805. doi:   10.1161/CIRCGENETICS.114.000696. Epub 2014 Aug 30. PMID: 25176937

X-Box Binding Protein-1 Dependent Plasma Cell Responses Limit the Development of Atherosclerosis.  Sage AP, Nus M, Bagchi Chakraborty J, Tsiantoulas D, Newland SA, Finigan AJ, Masters L, Binder CJ, Mallat Z.  Circ Res. 2017 Jul 21;121(3):270-281. doi:  10.1161/CIRCRESAHA.117.310884. Epub 2017 Jun 15. PMID: 28620068

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.   Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z.   Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986. PMID:  28656979

Senior Research Technician


Person keywords: 
innate immunity
adaptive immunity
cardiovascular disease