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Cambridge Cardiovascular



I am interested in how cytokines induce splenic monocytes to differentiate to splenic red pulp macrophages(RPM), which contribute to red blood cell homeostasis by phagocytosing senescent erythrocytes and releasing heme-associated iron for recycling during erythropoiesis. I have identified that IL-33 and IL-1 family cytokines, signalling via there receptors in co-operation with heme leads to changes in GATA transcription factor activity that promotes the differentiation of Monocyte to mature RPM.

I am also interested in the role of the adaptive immune system in atherosclerosis, such as immune cells migration ex-vivo and in vivo using multi-photon microscopy.

Other Collaborators


Key publications: 

Lu Y, Basatemur G, Scott IC, Chiarugi D, Clement M, Harrison J, Jugdaohsingh R, Yu X, Newland SA, Jolin HE, Li X, Chen X, Szymanska M, Haraldsen G, Palmer G, Fallon PG, Cohen ES, McKenzie ANJ, Mallat Z. Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages. Immunity. 2020 May 19;52(5):782-793.

Koch M, Cegla J, Jones B, Lu Y, Mallat Z, Blagborough AM, Angrisano F, Baum J. The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection. Malar J.  2019 Nov 29;18(1):381.

Raab M*, Lu Y*, Kohler K, Smith X, Strebhardt K, Rudd CE. LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T- cell conjugate formation. Nat Commun. 2017 Jul 12(8):16001

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017 May;23(5):601-610

Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. (2014) CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest. 2014 Oct 1;124(10):4603-13

Lu Y, Schneider H, Rudd CE. Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. Blood 2012 120(23):4560-70

Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd CE. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity 2010 32(4):541-56

Wang H, Lu Y, Rudd CE. SKAP1 is dispensable for chemokine-induced migration of primary T-cells. Immunol Lett. 2010 28(2):148-53

Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP- 55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007 27(19):6863-75

Pierce A, Lu Y, Hamzah HG, Thompson S, Owen-Lynch PJ, Whetton AD, Spooncer E. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation. Br J Haematology 2006 133(3):345-52

Lu Y, Evans CA, Spooncer E, Whetton AD. Stromal derived factor-1 and lysophospholipids mediate altered protein acetylation to promote progenitor cell migration. Experimental Hematology 2005 33 (7): 117-128

Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton AD. Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: Identification of the Rho pathway as a target of BCR/ABL. J Biol Chem. 2005 280(8): 6316-6326

Evans CA, Tonge R, Blinco D, Pierce A, Shaw J, Lu Y, Hamzah HG, Gray A, Downes CP, Gaskell SJ, Spooncer E, Whetton AD. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood 2004 103(10): 3751-9

Lu Y*, Whetton AD*, Pierce A, Carney L, Spooncer E. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav1. Blood 2003 102(8): 2798-802

Research Associate
 Yuning  Lu


Collaborator profiles: 
Departments and institutes: 
Person keywords: 
Cell migration
red pulp macrophage
Multi-photon microscopy