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Professor Bertie Göttgens

Research themes

Stem Cells:

Research Interests

Transcriptional Regulation of Blood Stem cells

My group uses a combination of experimental and computational approaches to study how transcription factor networks control the function of blood stem cells and how mutations that perturb such networks cause leukaemia. This integrated approach has resulted in the discovery of new combinatorial interactions between key blood stem cell regulators, as well as experimentally validated computational models for blood stem cells.

Current research focuses on

  1. single cell genomics of early blood development
  2. computer models to chart the transcriptional landscape of blood stem and progenitor cell differentiation
  3. transcriptional consequences of leukaemogenic mutations in leukaemia stem/progenitor cells
  4. molecular characterisation of human blood stem/progenitor cell populations used in cell and gene therapy protocols.


stem cells

Key Publications

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations. Wilson NK, Kent DG, Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B. Cell Stem Cell. 2015 Jun 4;16(6):712-24.

Decoding the regulatory network of early blood development from single-cell gene expression measurements. Moignard V, Woodhouse S, Haghverdi L, Lilly AJ, Tanaka Y, Wilkinson AC, Buettner F, Macaulay IC, Jawaid W, Diamanti E, Nishikawa S, Piterman N, Kouskoff V, Theis FJ, Fisher J, Göttgens B. Nat Biotechnol. 2015 Mar;33(3):269-76.

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Moignard V, Macaulay IC, Swiers G, Buettner F, Schütte J, Calero-Nieto FJ, Kinston S, Joshi A, Hannah R, Theis FJ, Jacobsen SE, de Bruijn MF, Göttgens B. Nat Cell Biol. 2013 Apr;15(4):363-72. Erratum in: Nat Cell Biol. 2013 May;15(5):544.

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Griffiths DS, Li J, Dawson MA, Trotter MW, Cheng YH, Smith AM, Mansfield W, Liu P, Kouzarides T, Nichols J, Bannister AJ, Green AR, Göttgens B. Nat Cell Biol. 2011 Jan;13(1):13-21.

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B. Cell Stem Cell. 2010 Oct 8;7(4):532-44.

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