Christian Doreth

Supervisor: Dr Xuan Li

Title: Identification and characterisation of NLRP3 interactome

Abstract: Aberrant activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, type 2 diabetes or Alzheimer’s disease. Identification of novel players regulating the NLRP3 inflammasome could therefore lead to the development of new therapeutic strategies.

Here, we propose to further characterize the NLRP3 interactome during inflammasome activation. We will then select and investigate the identified interaction partners in the NLRP3 inflammasome pathway. These experiments will not only shed light into the NLRP3 regulatory mechanism during inflammasome activation, but also reveal new role players in the NLRP3 inflammasome pathway.