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Cambridge Cardiovascular



I have recently returned to work in Cambridge, having spent 1 year at Barts Heart Centre/University College London/Great Ormond Street Hospital, London and 1 year at the Hopital Haut Leveque, Bordeaux. My primary interest is in the mechanisms of ventricular tachycardia initiation and propagation. I use novel high density contact mapping techniques and imaging with MRI and CT to investigate activation patterns of arrhythmias and link these to the presence of scar and wall thinning in patients with cardiomyopathy. The aim of my research is to design more effective and targeted strategies for patients undergoing ventricular ablation procedures.

Other ongoing areas of research are in the use of multi-polar catheters and novel algorithms to map atrial fibrillation, and in the use of 3-D printed models to improve outcome in left atrial appendage closure procedures.



Key publications:

  1. Bourier F, Duchateau J, Vlachos K, Lam A, Martin CA, Takigawa M, Kitamura T, Frontera A, Cheniti G, Pambrun T, Klotz N, Denis A, Derval N, Cochet H, Sacher F, Hocini M, Haïssaguerre M, Jais P. High power short duration vs. standard RF ablation: Insights on lesion metrics. J Cardiovasc Electrophysiol. 2018 doi: 10.1111/jce.13724
  2. Takigawa M, Derval N, Maury P, Martin R, Miyazaki S, Yamashita S, Frontera A, Vlachos K, Kitamura T, Cheniti G, Massouille G, Thompson N, Martin CA, Wolf M, Pillois X, Duchateau C, Klotz N, Duparc A, Rollin A, Pambrun T, Denis A, Sacher F, Cochet H, Hocini M, Haissaguerre M, Jaïs P. (2018) A comprehensive multi-center study of the common isthmus in post AF ablation multiple-loop atrial Tachycardia. Circ AE. 2018 Jun;11(6):e006019. doi: 10.1161/CIRCEP.117.006019.
  3. Takigawa M, Relan J, Martin R, Kim S, Kitamura T, Frontera A, Cheniti G, Vlachos K, Massoullié G, Martin CA, Thompson N, Wolf M, Bourier F, Lam A, Duchateau J, Klotz N, Pambrun T, Denis A, Derval N, Magat J, Naulin J, Merle M, Collot F, Quesson B, Cochet H, Hocini M, Haïssaguerre M, Sacher F, Jaïs P. The Importance of Bipolar Electrode Orientation on Local Electrogram Properties. Heart Rhythm. 2018 doi: 10.1016/j.hrthm.2018.07.020.
  4. Martin CA, Martin R, Maury P, Takigawa M, Kitamura T, Frontera A, Cheniti G, Duchateau J, Vlachos K, Bourier F, Lam A, Gajendragadkar P, Lord S; Murray S, Shephard E, Pambrun T, Denis A, Derval N, Jais P, Hocini M, Haissaguerre M, Sacher F. First clinical use of novel ablation catheter incorporating local impedance data. 2018.  J Cardiovasc Electrophysiol. 2018. doi: 10.1111/jce.13654.
  5. Takigawa M, Takahashi A, Tanaka Y, Martin CA, Nakashima E, Yamao K, Sagawa Y, Kuwahara T, Okubo K, Takahashi Y, Watari Y, Nakajima J, Takagi K, Fujino T, Kimura S, Hikita H, Hirao K. Simple and novel technique to confirm complete mitral isthmus block. J Cardiovasc Electrophysiol. 2018 doi: 10.1111/jce.13700.
  6. Martin CA*, Orini M*, Srinivasan N, Bhar-Amato J, Honarbakhsh S, Chow A, Lowe MD, Simon RD, Elliott PM, Taggart P, Lambiase PD (2018). Novel repolarisation metric predicts arrhythmia origin and clinical events in ARVC and Brugada Syndrome. In press. International Journal of Cardiology (*equal contributors)
  7. Wolf M, Sacher F, Cochet H., Kitamura T, Takigawa M, Yamashita S, Vlachos K, Cheniti G, Frontera A, Martin R, Thompson N, Massouille G, Lam A, Martin CA, Collot F, Duchateau J, Pambrun T, Denis A, Derval N, Hocini M, Haissaguerre M, Jaïs P. (2018) Long-term Outcome of Substrate Modification in Ablation of Post-Myocardial Infarction Ventricular Tachycardia. Circ AE. Circ Arrhythm Electrophysiol. 2018 Feb;11(2):e005635. doi: 10.1161/CIRCEP.117.005635.
  8. Kitamura T, Martin R, Denis A, Takigawa M, Duparc A, Rollin A, Frontera A, Thompson N, Massouille G, Cheniti G, Wolf M, Vlachos K, Martin CA, Al Jefairi N, Klotz N, Duchateau J, Pambrun T, Cochet H, Sacher F, Hocini M, Haissaguerre M, Maury P, Jaïs P, Derval N. (2018) Characteristics of single loop macroreentrant biatrial tachycardia diagnosed by ultra-high resolution mapping system. Circ AE. Circ Arrhythm Electrophysiol. 2018 Feb;11(2):e005558. doi: 10.1161/CIRCEP.117.005558.
  9. Takigawa M, Derval N, Frontera A, Martin R, Yamashita S, Cheniti G, Vlachos K, Thompson N, Kitamura T, Wolf M, Massoullie G, Martin C, Al-Jefairi N, Amraoui S, Duchateau J, Klotz N, Pambrun T, Denis A, Sacher F, Cochet H, Hocini M, Haissaguerre M, Jais P. Re-visiting anatomical macroreentrant tachycardia after atrial fibrillation ablation using ultra-high-resolution mapping: implications for ablation. Heart Rhythm. 2017 Oct 25. pii: S1547-5271(17)31243-2. doi: 10.1016/j.hrthm.2017.10.029. 
  10. Denis ASacher FDerval NMartin RLim HSPambrun TMassoullie GDuchateau JCochet HPillois XCheniti GFrontera ATakigawa MVlachos KMartin C, Kitamura THocini MDouard HJaïs PHaïssaguerre M. Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients. Europace. 2018 Feb 1. doi: 10.1093/europace/euy007.
  11. Honarbakhsh S, Schilling RJ, Providência R, Dhillon G, Martin CA, Sawhney V, Keating E, Finlay M, Ahsan S, Chow A, Earley MJ, Hunter R (2017). Panoramic atrial mapping with basket catheters: a quantitative analysis to optimize practice, patient selection and catheter choice.  J Cardiovasc Electrophysiol. 2017 Sep 1. doi: 10.1111/jce.13331.
  12. Martin CA, Curtain JP, Gajendragadkar PR, Begley DA, Fynn SP, Grace AA, Heck PM, Salaunkey K, Virdee MS, Agarwal S (2017). Improved outcome and cost effectiveness in ablation of persistent atrial fibrillation under general anaesthetic. Europace.
Consultant Cardiologist and Electrophysiologist
Afflilated Assistant Professor, University of Cambridge


Collaborator profiles: 
Person keywords: 
ventricular tachycardia
atrial fibrillation
inherited cardiac conditions
left artrial appendage closure
cardiac electrophysiology