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Cambridge Cardiovascular

 

Research

My research interests are in female specific risk factors for cardiovascular disease and high dimensional genomics

My PhD focused on the intersection between pregnancy loss and coronary heart disease in women, and my work continues to combine both women’s reproductive health and cardiovascular disease.

Currently I am investigating the risk of a range of cardiovascular outcomes in relation to parity. Overall, this work recognises that reproductive conditions affect more than the reproductive system and thus, obstetric history can be used as a marker of cardiovascular risk.

The second aspect of my research focuses on high dimensional genomics in cardiovascular disease, in the case of my work this investigates primarily lipids. This research has important implications for understanding and identifying causal genetic factors in the development of cardiovascular disease.

Publications

Key publications: 

Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme. Oliver-Williams C, Sweeting MJ, Turton G, Parkin D, Cooper D, Rodd C, Thompson SG, Earnshaw JJ; Gloucestershire and Swindon Abdominal Aortic Aneurysm Screening Programme. Br J Surg. 2018 Jan;105(1):68-74.

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. Ference BA, Kastelein JJP, Ginsberg HN, Chapman MJ, Nicholls SJ, Ray KK, Packard CJ, Laufs U, Brook RD, Oliver-Williams C, Butterworth AS, Danesh J, Smith GD, Catapano AL, Sabatine MS. JAMA. 2017 Sep 12;318(10):947-956.

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysis. Muka T*, Oliver-Williams C*, Kunutsor S, Laven JS, Fauser BC, Chowdhury R, Kavousi M, Franco OH. JAMA Cardiol. 2016 Oct 1;1(7):767-776. *Joint first author.

Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C*, Muka T*. JAMA. 2016 Jun 21;315(23):2554-63. *Joint corresponding author.

Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. Muka T*, Oliver-Williams C*, Colpani V, Kunutsor S, Chowdhury S, Chowdhury R, Kavousi M, Franco OH. PLoS One. 2016 Jun 17;11(6):e0157417. *Joint first author.

Previous caesarean delivery and the risk of unexplained stillbirth: retrospective cohort study and meta-analysis. Moraitis AA, Oliver-Williams C, Wood AM, Fleming M, Pell JP, Smith G. BJOG. 2015 Oct;122(11):1467-74.

Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980-2008: a historical cohort study. Oliver-Williams C, Fleming M, Wood AM, Smith G. BJOG. 2015 Oct;122(11):1525-34.

Changes in association between previous therapeutic abortion and preterm birth in Scotland, 1980 to 2008: a historical cohort study. Oliver-Williams C, Fleming M, Monteath K, Wood AM, Smith GC. PLoS Med. 2013;10(7):e1001481.

Miscarriage and future maternal cardiovascular disease: a systematic review and meta-analysis. Oliver-Williams CT, Heydon EE, Smith GC, Wood AM. Heart. 2013 Nov;99(22):1636-44.

Research Associate
Junior Research Fellow, Homerton College
Dr Clare  Oliver-Williams

Affiliations

Classifications: 
Person keywords: 
Miscarriage
Reproductive Health
High Dimensional Genomics
Infertility