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Professor Colin Taylor

Professor Colin Taylor

Professor of Cellular Pharmacology


Research Interests

Intracellular signalling pathways

Regulated changes in cytosolic Ca2+ concentration are the principal means by which contraction of vascular smooth muscle is controlled, and drugs that target Ca2+ signalling pathways are widely used to treat hypertension. Other signalling pathways, notably those regulated by cyclic AMP, modulate the responses of vascular smooth to contractile stimuli by both regulating Ca2+ signals and the effects they have on contractile proteins.

Building on our interests in IP3 receptors, which are the most widely expressed intracellular Ca2+ channels, we are examining the interplay between cAMP and Ca2+ in human aortic smooth muscle cells by examining responses to receptors that evoke IP3 and cAMP formation. A major aim is to understand how these diffusible messengers are delivered from receptors in the plasma membrane to their intracellular targets.

Keywords

cell signalling ; calcium signalling

Collaborators outside this directory

Key Publications

Most recent publications are listed on PubMed.

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs. Prole DL, Taylor CW. J Physiol. 2016 Feb 2. doi: 10.1113/JP271139. [Epub ahead of print]

Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration. Carrara G, Saraiva N, Parsons M, Byrne B, Prole DL, Taylor CW, Smith GL. J Biol Chem. 2015 May 1;290(18):11785-801.

Fluorescence methods for analysis of interactions between Ca(2+) signaling, lysosomes, and endoplasmic reticulum. Prole DL, López-Sanjurjo CI, Tovey SC, Taylor CW. Methods Cell Biol. 2015;126:237-59.

Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions. Meena A, Tovey SC, Taylor CW. J Cell Sci. 2015 Jan 15;128(2):408-20.

Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Wu J, Prole DL, Shen Y, Lin Z, Gnanasekaran A, Liu Y, Chen L, Zhou H, Chen SR, Usachev YM, Taylor CW, Campbell RE. Biochem J. 2014 Nov 15;464(1):13-22.

Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor. Saleem H, Tovey SC, Molinski TF, Taylor CW. Br J Pharmacol. 2014 Jul;171(13):3298-312.

Structural organization of signalling to and from IP3 receptors. Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T. Biochem Soc Trans. 2014 Feb;42(1):63-70.

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