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Cambridge Cardiovascular



Supervisor: Professor Ziad Mallat

Title: The effects of B cell activating factor (BAFF) on vascular and immune cell biology in Atherosclerosis

Abstract: In addition to innate immune responses, T and B lymphocytes play a role in atherosclerosis, a chronic inflammatory disease of the arterial wall. BAFF (B cell activating factor) is an essential cytokine for the survival and function of B cells. We hypothesise that excessive BAFF-mediated activation of immune responses contributes to the development of atherosclerosis. This project aims to characterise BAFF production in atherosclerotic mouse models using RT-PCR, ELISA and immuno-histochemistry. We will also utilise transgenic mice to study in detail how BAFF signalling through different receptors may modulate immune cell populations and function leading to the progression of atherosclerosis.


Key publications: 

MHC Class II-Restricted Antigen Presentation by Plasmacytoid Dendritic Cells Drives Pro-Atherogenic T Cell Immunity. Sage A, Murphy DM, Maffia P, Masters LM, Sabir SR, Baker LL, Cambrook H, Finigan AJ, Ait-Oufella H, Grassia G, Harrison JE, Ludewig B, Reith W, Hansson GK, Reizis B, Hugues S, Mallat Z. Circulation. 2014 Sep 15. pii: CIRCULATIONAHA.114.011090. [Epub ahead of print]

BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report. Sage AP, Tsiantoulas D, Baker L, Harrison J, Masters L, Murphy D, Loinard C, Binder CJ, Mallat Z. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1573-6.

BHF 4-Year Programme PhD Student
 Deirdre  Murphy