skip to primary navigationskip to content
 

Dr Dimitrios Tsiantoulas

Dr Dimitrios Tsiantoulas

Research Associate


Research Interests

Dissecting the role of B cell immunity in atherosclerosis and myocardial infarction

Heart attacks are the main causes of death worldwide. The main underlying pathology of this devastating condition is atherosclerosis, a lipid-driven chronic inflammatory disease that leads to the formation of an atherosclerotic plaque in large and medium size arteries.  Plaque rupture or erosion triggers thrombus formation, which restricts blood flow in the artery, thereby limiting oxygen supply to the heart muscle and consequently causing myocardial cell necrosis. B cells play a cardinal role both in atherosclerosis and post myocardial infarction injury. My research aims to dissect the mechanisms by which B cells impact these pathologies and identify the molecular machinery that governs the altered B cell responses in these settings. To achieve these goals, we study transgenic atherosclerosis-prone mice by employing state of the art techniques.

Other Collaborators

Prof.Christoph J Binder (Medical University of Vienna)

Prof. Pascal Schneider (University of Lausanne)

Keywords

antibodies ; Atherosclerosis ; innate immunity ; B lymphocytes ; myocardial infarction ; adaptive immunity

Collaborators

Cambridge Cardiovascular logo - transparent

Logo design by Dr Ana-Mishel Spiroski and Dr Sarah Morgan.

 

We connect cardiovascular researchers in Cambridge.

Please follow us on Twitter for local news about research, events, funding calls, and open positions.

For inquiries about our research or the website, please contact Dr Katja Kivinen.