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Dr Havovi Chichger

Research Interests

My research focuses on the cellular mechanisms which regulate the vasculature, including barrier integrity, proliferation, apoptosis and the angiogenic process.  In particular, I am interested in understanding mechanisms to reduce vascular dysfunction in settings of pulmonary diseases (Acute respiratory distress syndrome, Pulmonary hypertension, Pulmonary fibrosis and microvascular complications (Diabetes, Metabolic syndrome). 

My research has implicated various novel mechanisms in the regulation of vascular function, such as, endosomal adaptor proteins (LAMTOR and Rab), protein phosphatases (PTP and SHP) and protein kinases (MAPK and PKC).  My principal research is focused on studying the role of artificial sweeteners in regulating endothelial cell function, with the aim of reducing complications in settings of vascular disease.

Keywords

microvascular complications ; endocytic trafficking ; pulmonary hypertension ; pulmonary arterial hypertension ; acute respiratory distress syndrome ; angiogenesis ; endothelial cell biology ; diabetes

Collaborators outside this directory

Key Publications

Harrington EO, Vang A, Braza J, Shil A, Chichger H.  Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2017) Epub ahead of print.

Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O’Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2017) 312 (5):L748-L759.

Chichger H, Cleasby M, Srai KS, Debnam ES, Unwin R.J, Marks J. Differential regulation of renal glucose transporters: Implications for diabetic nephropathy.  Experimental Physiology.  (2016) 101 (6):731-42.

Chichger H, Braza J, Duong H, Boni G, Harrington EO.  Select Rab GTPases regulate the pulmonary endothelium via endosomal trafficking of VE-cadherin.  American Journal of Respiratory Cell and Molecular Biology. (2016) 54 (6):739-81.

Chichger H, Braza J, Duong H, Stark M, Harrington EO. Vasculogenesis in the pulmonary endothelium dysregulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling.  American Journal of Physiology – Lung Cellular and Molecular Physiology. (2015) 309 (7):L700.

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