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Cambridge Cardiovascular



I manage cardiovascular research in Cambridge through three main avenues:

Cardiovascular Strategic Research Initiative (2013-2016, renewed 2016-2019) hosts this website and provides resources for organising seminars and events of all sizes.

Cambridge BHF Centre of Research Excellence (2014-2019) promotes multi-disciplinary research with focus on atherothrombosis. The Centre offers support through pump-priming funds and early career positions (PhD Studentships; Clinical Research Fellowships; Career Development Fellowships).

Oxbridge BHF Centre of Regenerative Medicine (2013-2017, renewed 2017-2021) is a joint effort between the Universities of Oxford, Cambridge, Bristol, and Manchester. It supports research through pump-priming funding and early career positions (PhD studentships 2013-2017; Postdoctoral Research Associates).

I was a senior scientist/manager/bioinformatician in my previous life, and still do some pre-eclampsia (FINNPEC; InterPregGen) and malaria (MalariaGEN) research during my free time. See below for relevant papers.

I focus on connecting researchers, raising awareness of cardiovascular research, and bringing more research money to Cambridge. Please contact me if you would like to join our community, if you would like to identify collaborators within Cambridge, or if you have an idea for an activity or an event!


Key publications: 

I'm only listing pre-eclampsia and malaria papers here - please check PubMed for a more comprehensive list of publications.

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia. Kaartokallio T, Utge S, Klemetti MM, Paananen J, Pulkki K, Romppanen J, Tikkanen I, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Hypertension. 2018 Jan;71(1):95-102.

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population. Lokki AI, Daly E, Triebwasser M, Kurki MI, Roberson EDO, Häppölä P, Auro K, Perola M, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Salmon JE, Meri S, Daly M, Atkinson JP, Laivuori H. Hypertension. 2017 Aug;70(2):365-371.

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, ..., FINNPEC Consortium, ..., Laivuori H, Stefansson K, Morgan L. Nat Genet. 2017 Aug;49(8):1255-1260.

Resistance to malaria through structural variation of red blood cell invasion receptors. Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, ..., Rockett KA, Spencer CCA, Kwiatkowski DP; Malaria Genomic Epidemiology Network. Science. 2017 Jun 16;356(6343).

Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC). Jääskeläinen T, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H; FINNPEC Study Group. BMJ Open. 2016 Nov 10;6(11):e013148.

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia. Clarke GM, Rockett K, Kivinen K, ..., Farrar J, Marsh K, Taylor T, Kwiatkowski DP; MalariaGEN Consortium. Elife. 2017 Jan 9;6.

An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women. Karppanen T, Kaartokallio T, Klemetti MM, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Staff AC, Laivuori H. BMC Genet. 2016 Aug 24;17(1):121.

The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort. Kallela J, Jääskeläinen T, Kortelainen E, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H. BMC Pregnancy Childbirth. 2016 Aug 12;16:221.

Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants. Kaartokallio T, Wang J, Heinonen S, Kajantie E, Kivinen K, Pouta A, Gerdhem P, Jiao H, Kere J, Laivuori H. Sci Rep. 2016 Jul 7;6:29085.

Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. Kaartokallio T, Lokki AI, Peterson H, Kivinen K, ..., Brennecke SP, Johnson MP, Morgan L, Moses EK, Kere J, Laivuori H. Ann Med. 2016 Apr 25:1-7.

A novel locus of resistance to severe malaria in a region of ancient balancing selection. Malaria Genomic Epidemiology Network. Nature. 2015 Oct 8;526(7572):253-7.

Gene expression profiling of pre-eclamptic placentae by RNA sequencing. Kaartokallio T, Cervera A, Kyllönen A, Laivuori K; FINNPEC Core Investigator Group. Sci Rep. 2015 Sep 21;5:14107.

Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. Lokki AI, Aalto-Viljakainen T, Meri S, Laivuori H; FINNPEC. PLoS One. 2015 Feb 24;10(2):e0117840.

The African Genome Variation Project shapes medical genetics in Africa. Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I, Hatzikotoulas K, Karthikeyan S, Iles L, Pollard MO, Choudhury A, Ritchie GR, Xue Y, Asimit J, Nsubuga RN, Young EH, Pomilla C, Kivinen K, Rockett K, ..., Kwiatkowski D, Tyler-Smith C, Rotimi C, Zeggini E, Sandhu MS. Nature. 2015 Jan 15;517(7534):327-32.

Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya. Shah SS, Macharia A, Makale J, Uyoga S, Kivinen K, Craik R, Hubbart C, Wellems TE, Rockett KA, Kwiatkowski DP, Williams TN. BMC Med Genet. 2014 Sep 9;15:93.

Microsatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia. Kaartokallio T, Klemetti MM, Timonen A, Uotila J, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Hypertension. 2014 Jul;64(1):172-7.

Imputation-based meta-analysis of severe malaria in three African populations. Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, ..., Kwiatkowski DP, Rockett KA, Barrett JC, Spencer CC; Malaria Genomic Epidemiology Network. PLoS Genet. 2013 May;9(5):e1003509.

Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease. Johnson MP, Brennecke SP, East CE, Dyer TD, Roten LT, Proffitt JM, Melton PE, Fenstad MH, Aalto-Viljakainen T, Mäkikallio K, Heinonen S, Kajantie E, Kere J, Laivuori H; FINNPEC Study Group, Austgulen R, Blangero J, Moses EK. Mol Hum Reprod. 2013 Jul;19(7):423-37.

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18. Majander KK, Villa PM, Kivinen K, Kere J, Laivuori H. Eur J Hum Genet. 2013 Sep;21(9):1024-6.

Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. Johnson MP, Brennecke SP, East CE, Göring HH, Kent JW Jr, Dyer TD, Said JM, Roten LT, Iversen AC, Abraham LJ, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H; FINNPEC Study Group, Austgulen R, Blangero J, Moses EK. PLoS One. 2012;7(3):e33666.

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay. Campino S, Auburn S, Kivinen K, Zongo I, ..., Rockett K, Clark TG, Kwiatkowski DP. PLoS One. 2011;6(6):e20251.

Genome-wide and fine-resolution association analysis of malaria in West Africa. Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, ..., Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network. Nat Genet. 2009 Jun;41(6):657-65.

ROCK2 allelic variants are not associated with pre-eclampsia susceptibility in the Finnish population. Peterson H, Laivuori H, Kerkelä E, Jiao H, Hiltunen L, Heino S, Tiala I, Knuutila S, Rasi V, Kere J, Kivinen K. Mol Hum Reprod. 2009 Jul;15(7):443-9.

A global network for investigating the genomic epidemiology of malaria. Malaria Genomic Epidemiology Network. Nature. 2008 Dec 11;456(7223):732-7.

Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Kivinen K, Peterson H, Hiltunen L, Laivuori H, Heino S, Tiala I, Knuutila S, Rasi V, Kere J. Eur J Hum Genet. 2007 Apr;15(4):494-7.

Research Director FIMM
Dr Katja  Kivinen

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Person keywords: 
website management
strategic planning
public engagement
research management
research communication