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Ryan Chung

Ryan Chung

BHF 4-Year Programme PhD Student


Research Interests

Title: Advancing CVD risk prediction models in younger individuals

Abstract: Cardiovascular disease is still one of the largest killers in the world. Over the past 20 years, risk scores such as the Framingham score have become a helpful tool to identify individuals who are at risk of a future cardiovascular event. By using a handful of risk factors, risk scores help to inform clinical decisions such as prescribing anti-hypertensive medication or statins. However, due to the use of set clinical thresholds to determine who is high risk or not, these scores often fail to identify young individuals as high risk, regardless of whether their risk factors, such as cholesterol or blood pressure, are high. Therefore, identifying high risk individuals and intervening earlier before atherosclerosis develops is key. This PhD aims to advance risk prediction in younger individuals by using large omics data to pre-stratify and to inform these decisions. Health economics will be utilised, a clinical tool will be built and optimal risk thresholds will be investigated.

 

Keywords

genomics ; risk stratification ; proteomics ; metabolomics ; risk prediction

Collaborators

Key Publications

Biases incurred from nonrandom repeat testing of haemoglobin levels in blood donors: Selective testing and its implications (https://onlinelibrary.wiley.com/doi/full/10.1002/bimj.201700268)

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