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Professor Susan Ozanne

Professor Susan Ozanne

Professor of Developmental Endocrinology


Research Interests

Developmental programming of cardiovascular and metabolic disease

The major research aims of my laboratory are to understand the mechanisms by which suboptimal growth and nutrition in early life lead to increased risk of type 2 diabetes, cardiovascular disease, obesity and premature death.

To achieve these goals, we incorporate the study of both rodent models and human biopsy material (including muscle, adipose tissue and placenta) as well as studies in cell culture. The parallel approach of studies in humans and animal models has enabled us to define the fundamental molecular processes that underpin this concept that has been termed developmental programming. This involves the study of changes in the transcriptome, proteome, epigenome and mitochondrial function.

In the long term, our work can lead to the identification of key predictive biomarkers for the early diagnosis and prevention of type 2 diabetes, cardiovascular disease and obesity.

Keywords

nutritional programming ; miRNAs ; insulin resistance ; metabolic phenotyping ; maternal diet

Key Publications

Most recent publications are listed on PubMed.

Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Diabetologia. 2016 Mar 10. [Epub ahead of print]

Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth. Tarry-Adkins JL, Fernandez-Twinn DS, Hargreaves IP, Neergheen V, Aiken CE, Martin-Gronert MS, McConnell JM, Ozanne SE. Am J Clin Nutr. 2016 Feb;103(2):579-88.

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M. Diabetologia. 2016 Mar;59(3):502-11.

Transgenerational Developmental Programming of Ovarian Reserve. Aiken CE, Tarry-Adkins JL, Ozanne SE. Sci Rep. 2015 Nov 3;5:16175.

Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth. Tarry-Adkins JL, Fernandez-Twinn DS, Madsen R, Chen JH, Carpenter A, Hargreaves IP, McConnell JM, Ozanne SE. Endocrinology. 2015 Oct;156(10):3528-37.

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity. Bouret S, Levin BE, Ozanne SE. Physiol Rev. 2015 Jan;95(1):47-82.

Programming of cardiovascular disease across the life-course. Blackmore HL, Ozanne SE. J Mol Cell Cardiol. 2014 Dec 12.

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes. Bork-Jensen J, Scheele C, Christophersen DV, Nilsson E, Friedrichsen M, Fernandez-Twinn DS, Grunnet LG, Litman T, Holmstrøm K, Vind B, Højlund K, Beck-Nielsen H, Wojtaszewski J, Ozanne SE, Pedersen BK, Poulsen P, Vaag A. Diabetologia. 2015 Feb;58(2):363-73.

Nutritional programming of coenzyme Q: potential for prevention and intervention? Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Martin-Gronert MS, McConnell JM, Ozanne SE. FASEB J. 2014 Dec;28(12):5398-405.

Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight. Blackmore HL, Niu Y, Fernandez-Twinn DS, Tarry-Adkins JL, Giussani DA, Ozanne SE. Endocrinology. 2014 Oct;155(10):3970-80.

Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study. Bork-Jensen J, Thuesen AC, Bang-Bertelsen CH, Grunnet LG, Pociot F, Beck-Nielsen H, Ozanne SE, Poulsen P, Vaag A. Genes (Basel). 2014 Jul 9;5(3):508-17.

The effect of placental restriction on insulin signaling and lipogenic pathways in omental adipose tissue in the postnatal lamb. Lie S, Duffield JA, McMillen IC, Morrison JL, Ozanne SE, Pilgrim C, Muhlhausler BS. J Dev Orig Health Dis. 2013 Oct;4(5):421-9.

Maternal diet-induced obesity and offspring cardiovascular health. Blackmore HL, Ozanne SE. J Dev Orig Health Dis. 2013 Oct;4(5):338-47.

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. Alfaradhi MZ, Fernandez-Twinn DS, Martin-Gronert MS, Musial B, Fowden A, Ozanne SE. Am J Physiol Regul Integr Comp Physiol. 2014 Jul 1;307(1):R26-34.

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Fernandez-Twinn DS, Alfaradhi MZ, Martin-Gronert MS, Duque-Guimaraes DE, Piekarz A, Ferland-McCollough D, Bushell M, Ozanne SE. Mol Metab. 2014 Jan 20;3(3):325-33.

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