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Cambridge Cardiovascular



My work focuses on intracellular calcium signalling mechanisms and the roles of calcium signals in platelet function. Much of my work has concerned the mechanisms which generate calcium entry and in particular on the mechanisms which couple the depletion of the intracellular calcium stores to the activation of calcium entry. This work employs fluorescent indicators and protein chemistry.


Key publications: 

Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. Sage SO, Pugh N, Farndale RW, Harper AG. Physiol Rep. 2013 Oct;1(5):e00085.

The TRPV1 ion channel is expressed in human but not mouse platelets. Sage SO, Jarvis GE, Jardín I, Rosado JA, Harper AG. Platelets. 2014;25(5):390-2.

STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets. Lopez E, Jardin I, Berna-Erro A, Bermejo N, Salido GM, Sage SO, Rosado JA, Redondo PC. Cell Signal. 2012 Jun;24(6):1315-22.

Monitoring the intracellular store Ca2+ concentration in agonist-stimulated, intact human platelets by using Fluo-5N. Sage SO, Pugh N, Mason MJ, Harper AG. J Thromb Haemost. 2011 Mar;9(3):540-51.

Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets. Harper MT, Sage SO. Platelets. 2010;21(6):445-50.

Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry. Harper MT, Mason MJ, Sage SO, Harper AG. J Thromb Haemost. 2010 Jul;8(7):1604-13.

Reader in Cell Physiology