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Cambridge Cardiovascular

Atherosclerosis Imaging
Contrast induced- acute kidney injury
Ischaemic Pre- and post- conditioning


We develop Magnetic Resonance Imaging (MRI) methods to view atherosclerotic plaques. My interests lie in studying the applied biomechanics of atherosclerotic plaques and other cardiovascular pathologies; assessing novel strategies to prevent contrast induced- acute kidney injury and understanding the utility of ischaemic pre- and post-conditioning in patients undergoing open/endovascular vascular surgery procedures.


Key publications: 

More publications are available through PubMed.


Sadat U, Jaffer FA, van Zandvoort MA, Nicholls SJ, Ribatti D, Gillard JH. Inflammation and neovascularization intertwined in atherosclerosis: imaging of structural and molecular imaging targets. Circulation. 2014 Aug 26;130(9):786-94.

Sadat U, Li ZY, Graves MJ, Tang TY, Gillard JH. Noninvasive imaging of atheromatous carotid plaques. Nat Clin Pract Cardiovasc Med. 2009 Mar;6(3):200-9.

Sadat U, Teng Z, Young VE, Graves MJ, Gaunt ME, Gillard JH. High-resolution
magnetic resonance imaging-based biomechanical stress analysis of carotid
atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups. Eur J Vasc Endovasc Surg. 2011 Jan;41(1):83-90.

Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, Varty K, Gillard JH. Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events--a longitudinal in vivo magnetic resonance imaging-based finite element study. Eur J Vasc Endovasc Surg2010 Oct;40(4):485-91.

Sadat U, Li ZY, Young VE, Graves MJ, Boyle JR, Warburton EA, Varty K, O'Brien
E, Gillard JH. Finite element analysis of vulnerable atherosclerotic plaques: a
comparison of mechanical stresses within carotid plaques of acute and recently symptomatic patients with carotid artery disease. J Neurol Neurosurg Psychiatry. 2010 Mar;81(3):286-9.

Sadat U, Weerakkody RA, Bowden DJ, Young VE, Graves MJ, Li ZY, Tang TY, Gaunt ME, Hayes PD, Gillard JH. Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease. Atherosclerosis. 2009 Dec;207(2):434-9.

Sadat U, Taviani V, Patterson AJ, Young VE, Graves MJ, Teng Z, Tang TY,
Gillard JH. Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms--a feasibility study. Eur J Vasc Endovasc Surg. 2011 Feb;41(2):167-74.

Abbadi RA, Sadat U, Jah A, Praseedom RK, Jamieson NV, Cheow HK, Whitley S,
Ford HE, Wilson CB, Harper SJ, Huguet EL. Improved long-term survival after
resection of colorectal liver metastases following staging with FDG positron
emission tomography. J Surg Oncol. 2014 Sep;110(3):313-9.

Sadat U, Usman A, Gillard JH, Boyle JR. Does ascorbic acid protect against
contrast-induced acute kidney injury in patients undergoing coronary angiography: a systematic review with meta-analysis of randomized, controlled trials. J Am Coll Cardiol. 2013 Dec 10;62(23):2167-75.

Sadat U, Walsh SR, Norden AG, Gillard JH, Boyle JR. Does oral N-acetylcysteine
reduce contrast-induced renal injury in patients with peripheral arterial disease undergoing peripheral angiography? A randomized-controlled study. Angiology. 2011 Apr;62(3):225-30.

Sadat U, Huguet EL, Varty K. Abdominal aortic aneurysm surgery in renal,
cardiac and hepatic transplant recipients. Eur J Vasc Endovasc Surg. 2010

Sadat U, Varty K. Preconditioning or postconditioning in hepatic surgery.
Arch Surg. 2008 Oct;143(10):1026; author reply 1026.

Sadat U, Boyle JR, Walsh SR, Tang T, Varty K, Hayes PD. Endovascular vs open
repair of acute abdominal aortic aneurysms--a systematic review and
meta-analysis. J Vasc Surg. 2008 Jul;48(1):227-36.

Clinical Lecturer
Dr Umar  Sadat


Departments and institutes: 
Person keywords: 
ischaemic preconditioning