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Cambridge Cardiovascular

Biomedical Engineering


Most strokes and cardiac infarctions are due to atherosclerotic plaques rupture. High risk features, including fiber cap rupture/erosion and presence of intraplaque haemorrhage, have been proved to be more relevant than the degree of stenosis in differentiating patient clinical presentation and predicting subsequent adverse events. Moreover, under physiological conditions, lesions are subject to mechanical loading induced by blood pressure and flow. Plaque structure may fail if such loading exceeds its material strength. With this relevance, I am interested in the translational application of the combination of vascular wall imaging and biomechanical analysis. Non/mini-invasive imaging modalities, including MRI, PET/CT, VH-IVUS and OCT, are used to visualise morphological and compositional features of atherosclerotic lesions and mechanical analysis is employed to quantify the loading, including tensile stress, stretch and shear stress.

Other Collaborators:

Dr Michael PF Sutcliffe (Engineering, Cambridge)

Dr Pietro Lio (Computer Lab, Cambridge)

Prof Jianping Lu (Dept Radiology, Changhai Hospital, Shanghai)

Prof Qingsheng Lu (Vascular Surgery, Changhai Hospital, Shanghai)


Key publications: 

Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging. Brown AJ, Teng Z, Calvert PA, Rajani NK, Hennessy O, Nerlekar N, Obaid DR, Costopoulos C, Huang Y, Hoole SP, Goddard M, West NE, Gillard JH, Bennett MR. Circ Cardiovasc Imaging. 2016 Jun;9(6).

From Ultrasonography to High Resolution Magnetic Resonance Imaging: Towards an Optimal Management Strategy for Vulnerable Carotid Atherosclerotic Plaques. Teng Z, Brown AJ, Gillard JH. EBioMedicine. 2016 Jan 6;3:2-3.

Role of biomechanical forces in the natural history of coronary atherosclerosis. Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR. Nat Rev Cardiol. 2016 Apr;13(4):210-20.

The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques. Teng Z, Yuan J, Feng J, Zhang Y, Brown AJ, Wang S, Lu Q, Gillard JH. J Biomech. 2015 Nov 5;48(14):3912-21.

A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques. Teng Z, Feng J, Zhang Y, Sutcliffe MP, Huang Y, Brown AJ, Jing Z, Lu Q, Gillard JH. J Biomech. 2015 Nov 5;48(14):3859-67.

Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma. Brown AJ, Obaid DR, Costopoulos C, Parker RA, Calvert PA, Teng Z, Hoole SP, West NE, Goddard M, Bennett MR. Circ Cardiovasc Imaging. 2015 Oct;8(10):e003487.

An assessment on the incremental value of high-resolution magnetic resonance imaging to identify culprit plaques in atherosclerotic disease of the middle cerebral artery. Teng Z, Peng W, Zhan Q, Zhang X, Liu Q, Chen S, Tian X, Chen L, Brown AJ, Graves MJ, Gillard JH, Lu J. Eur Radiol. 2016 Jul;26(7):2206-14.

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis. Costopoulos C, Brown AJ, Teng Z, Hoole SP, West NE, Samady H, Bennett MR. Int J Cardiovasc Imaging. 2016 Jan;32(1):189-200.

Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: a 3D fluid-structure interaction analysis. Yuan J, Teng Z, Feng J, Zhang Y, Brown AJ, Gillard JH, Jing Z, Lu Q. Int J Numer Method Biomed Eng. 2015 Aug;31(8).

Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study. Teng Z, Feng J, Zhang Y, Huang Y, Sutcliffe MP, Brown AJ, Jing Z, Gillard JH, Lu Q. Ann Biomed Eng. 2015 Nov;43(11):2745-59.

More publications available through Pubmed.


Senior Research Associate
Dr Zhongzhao  Teng


Person keywords: 
aortic aneurysm
computer modelling