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Dr Julian Griffin

Dr Julian Griffin

University Reader in Human Metabolism and Nutrition

Group leader at MRC Human Nutrition Research


Research Interests

Metabolomics

My focus is on the use of high resolution mass spectrometry to measure lipids in biofluids and tissue extracts in order to better understand the causes and consequences of type 2 diabetes and obesity (sometimes collectively referred to as the Metabolic Syndrome).

I am particularly interested in four areas of research:

  1. understanding the role that peroxisome proliferator activated receptors (PPARs) play in regulating metabolism across the body
  2. understanding how lipids influence the function of the cell and hence why changes in lipid intake affect how the body functions
  3. examining how lipids influence tissue inflammation in the Metabolic syndrome
  4. developing computer software tools for storing and processing the large quantity of data produced by these experiments.

Keywords

metabolomics ; functional genomics ; bioinformatics

Key Publications

Most recent publications are available through PubMed.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access. Salek RM, Neumann S, Schober D, Hummel J, Billiau K, Kopka J, Correa E, Reijmers T, Rosato A, Tenori L, Turano P, Marin S, Deborde C, Jacob D, Rolin D, Dartigues B, Conesa P, Haug K, Rocca-Serra P, O'Hagan S, Hao J, van Vliet M, Sysi-Aho M, Ludwig C, Bouwman J, Cascante M, Ebbels T, Griffin JL, Moing A, Nikolski M, Oresic M, Sansone SA, Viant MR, Goodacre R, Günther UL, Hankemeier T, Luchinat C, Walther D, Steinbeck C. Metabolomics. 2015;11(6):1587-1597.

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes. Eiden M, Koulman A, Hatunic M, West JA, Murfitt S, Osei M, Adams C, Wang X, Chu Y, Marney L, Roberts LD, O'Rahilly S, Semple RK, Savage DB, Griffin JL. Genome Med. 2015 Jun 28;7(1):63.

Regulation of mitochondrial morphology and function by stearoylation of TFR1. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Nature. 2015 Sep 3;525(7567):124-8.

Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart. Wang X, West JA, Murray AJ, Griffin JL. J Proteome Res. 2015 Jul 2;14(7):2849-62.

Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Roberts LD, Ashmore T, Kotwica AO, Murfitt SA, Fernandez BO, Feelisch M, Murray AJ, Griffin JL. Diabetes. 2015 Feb;64(2):471-84.

Obesity in mice with adipocyte-specific deletion of clock component Arntl. Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA. Nat Med. 2012 Dec;18(12):1768-77.

Metabolomics as a tool for cardiac research. Griffin JL, Atherton H, Shockcor J, Atzori L. Nat Rev Cardiol. 2011 Sep 20;8(11):630-43.

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