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Dr Joanna Howson

Research themes

Epidemiology:

Research Interests

I focus on statistical methods for common and rare copy number variant analysis. Currently I am exploring rare variant and pathway analysis methods for use with SNP chip genotype data, with application to cardiovascular disease.

I investigate inflammation related genes and pathways and their effects on cardiovascular disease risk in collaboration with Drs Anders Malarstig and Nadeem Sarwar at Pfizer.

Keywords

epidemiology ; genetic variation ; statistical analysis ; statistical and computational methods

Key Publications

Exome-wide association study of plasma lipids in >300,000 individuals. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, ..., Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S. Nat Genet. 2017 Dec;49(12):1758-1766.

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, ..., Howson JMM; CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group†. Circ Cardiovasc Genet. 2017 Oct;10(5).

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, ..., Danesh J, Voight BF, Saleheen D. Nat Genet. 2017 Oct;49(10):1450-1457.

Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, ..., Howson JMM, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt EE, Schmidt AF, Sweeting MJ, Zalloua PA, AlGhalayini K, Keavney BD, Kooner JS, Loos RJF, Patel RS, Rutter MK, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren JLM; EPIC-CVD Consortium; CARDIoGRAMplusC4D; UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H, Farrall M, Danesh J, Samani NJ, Watkins H, Deloukas P. Nat Genet. 2017 Sep;49(9):1385-1391.

A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design. Staley JR, Jones E, Kaptoge S, Butterworth AS, Sweeting MJ, Wood AM, Howson JMM. Eur J Hum Genet. 2017 Jun;25(7):854-862.

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, Sun BB, Eicher JD, Johnson AD, Sheu WHH, Nielsen SF, Lin WY, Surendran P, Malarstig A, Wilk JB, Tybjærg-Hansen A, Rasmussen KL, Kamstrup PR, Deloukas P, Erdmann J, Kathiresan S, Samani NJ, Schunkert H, Watkins H; CARDIoGRAMplusC4D, Do R, Rader DJ, Johnson JA, Hazen SL, Quyyumi AA, Spertus JA, Pepine CJ, Franceschini N, Justice A, Reiner AP, Buyske S, Hindorff LA, Carty CL, North KE, Kooperberg C, Boerwinkle E, Young K, Graff M, Peters U, Absher D, Hsiung CA, Lee WJ, Taylor KD, Chen YH, Lee IT, Guo X, Chung RH, Hung YJ, Rotter JI, Juang JJ, Quertermous T, Wang TD, Rasheed A, Frossard P, Alam DS, Majumder AAS, Di Angelantonio E, Chowdhury R; EPIC-CVD, Chen YI, Nordestgaard BG, Assimes TL, Danesh J, Butterworth AS, Saleheen D. Nat Genet. 2017 Jul;49(7):1113-1119.

More publications are available through PubMed.

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