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Professor Ken Smith

Professor Ken Smith

Genzyme Professor of Experimental Medicine


Office Phone: 01223 762645

Keywords

clinical immunology ; autoimmunity

Key Publications

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G and Smith KGC (2017). “Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.” J Exp Med. 214(4):1111-1128. doi: 10.1084/jem.20161382

Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA; UK IBD Genetics Consortium., Traherne JA, Lyons PA, Parkes M and Smith KGC (2017). “Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.” Nat Genet. 49(2):262-268. doi: 10.1038/ng.3755

Peters JE, Lyons PA, Lee JC, Richard AC, Fortune MD, Newcombe PJ, Richardson S and Smith KGC (2016). “Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune-mediated disease.” PLoS Genet.12(3):e1005908. doi: 10.1371/journal.pgen.1005908

McKinney EF, Lee, JC, Jayne DRW, Lyons PA and Smith KGC (2015). T cell exhaustion, costimulation and clinical outcome in autoimmunity and infection. Nature 523(7562): 612-616. doi: 10.1038/nature14468.

Linterman, MA, Denton, AE, Divekar, DP, Zvetkova, I, Kane, L, Ferreira, C, Veldhoen, M, Clare, S, Dougan G, Espéli, M, and Smith, KGC(2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. ELIFE3. doi:10.7554/eLife.03180

LeeJC, EspéliM, AndersonCA, LintermanMA, PocockJM, WilliamsNJ, RobertsR, ViatteS, FuB,   PeshuN, Tran TH, Nguyen HP, WesleyE, EdwardsC, AhmadT, MansfieldJC, GearryR, DunstanS,   Williams TS, BartonA, VinuesaCG, UK IBD Genetics Consortium, ParkesM, LyonsPA, SmithKGC.  Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.  Cell 2013: 155(1):57-69. 

Marion Espéli, Menna R. Clatworthy, Susanne Bökers, Kate E. Lawlor, Antony J. Cutler, Frank Köntgen, Paul A. Lyons, Kenneth G. C. Smith. Analysis of a wild mouse Fcgr2b promoter variant reveals a novel role for FcgRIIb in the control of the germinal center and autoimmunity. J Exp Med, 2012  Nov 19;209(12):2307-19.

Lyons PA*, Rayner TF*, Trivedi S*, Holle JU, Watts RA, Jayne DRW, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L,Gunnarsson I, Harper L, Hrušková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders J-S F, Savage CO, Segelmark M, Stegeman CA, Tesař V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG and Smith KGC. Genetically Distinct Subsets within ANCA-Associated Vasculitis New England Journal of Medicine, 2012 Jul 19;367(3):214-23.
 
Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, Rayner TF, Srivastava M, Divekar DP, Beaton L, Hogan JJ, Fagarasan S, Liston A, Smith KGC* & Vinuesa CG*. Foxp3+ follicular regulatory T cells control the germinal center response. Nature Medicine, 2011
 
Lee JC, Lyons PA, McKinney EF, Sowerby JM, Carr EJ, Bredin F, Rickman HM, Ratlamwala H, Hatton A, Rayner TF, Parkes M, Smith KGC. Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. Journal of Clinical Investigation, 2011; 121:4170-9.

 

McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DRW, Willcocks LC, Koukoulaki M, Hatton  A, MacAry PA, Brazma A, Chaudhry AN and Smith KGC.  A CD8 memory T cell transcription signature predicts prognosis in autoimmune diseases. Nature Medicine,  2010; in press. Nat Med 16(5): 586-591, 581p following 591.

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